CAS 59787-61-0|Thr2-Cyclosporine
Introduction：Basic information about CAS 59787-61-0|Thr2-Cyclosporine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Thr2-Cyclosporine | ||
|---|---|---|---|
| CAS Number | 59787-61-0 | Molecular Weight | 1218.611 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 1316.0±65.0 °C at 760 mmHg |
| Molecular Formula | C62H111N11O13 | Melting Point | 152-155ºC |
| MSDS | USA | Flash Point | 749.7±34.3 °C |
Names
| Name | Cyclosporin C |
|---|---|
| Synonym | More Synonyms |
Thr2-Cyclosporine BiologicalActivity
| Description | Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. Cyclosporin C is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs=0.1-5 μg/ml). |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>FungalSignaling Pathways >>Anti-infection >>Bacterial |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 1316.0±65.0 °C at 760 mmHg |
| Melting Point | 152-155ºC |
| Molecular Formula | C62H111N11O13 |
| Molecular Weight | 1218.611 |
| Flash Point | 749.7±34.3 °C |
| Exact Mass | 1217.836304 |
| PSA | 299.03000 |
| LogP | 2.11 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.472 |
| InChIKey | JTOKYIBTLUQVQV-YRQGTVDASA-N |
| SMILES | CC=CCC(C)C(O)C1C(=O)NC(C(C)O)C(=O)N(C)CC(=O)N(C)C(CC(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(C(C)C)C(=O)N1C |
Safety Information
| Hazard Codes | Xn |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles18
More Articles| Comparison of the properties of the CsA analogs monoacetyl CyC (o-acetyl-threonine2 cyclosporin) and methyl-alanyl CsA (N-methyl-L-alanyl6 cyclosporin); monoacetyl cyclosporin is immunosuppressive without binding to cyclophilin. Clin. Exp. Immunol. 89(1) , 136-42, (1992) Cyclosporin (CsA) is an immunosuppressant which binds to cyclophilin (Cyp). The relationship between Cyp binding and immunosuppression has been questioned since one of the analogs of CsA, N-methyl-L-a... | |
| Tachykinin antagonists screening from microbial origin. J. Antibiot. 49(1) , 110-2, (1996) | |
| Monitoring cyclosporine by HPLC with cyclosporin C as internal standard. Clin. Chem. 39(1) , 168, (1993) |
Synonyms
| Thr2-Cyclosporine |
| 30-(1-Hydroxyethyl)-33-[(4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone |
| 30-(1-hydroxyethyl)-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone |
| 30-(1-Hydroxyethyl)-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone |
| CyclosporinC |
| 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 30-(1-hydroxyethyl)-33-[(4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)- |
| 7-L-Threoninecyclosporin A |
| WF-3484 |
| Cyclosporin Impurity 3 |
