Introduction：Basic information about CAS 201530-41-8|Deferasirox, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Deferasirox |
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| CAS Number | 201530-41-8 | Molecular Weight | 373.362 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 672.1±65.0 °C at 760 mmHg |
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| Molecular Formula | C21H15N3O4 | Melting Point | 260-262ºC |
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| MSDS | / | Flash Point | 360.3±34.3 °C |
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Names
| Name | deferasirox |
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| Synonym | More Synonyms |
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Deferasirox BiologicalActivity
| Description | Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
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| In Vitro | In LX-2 cells treated with 50 μM deferasirox for 12 h, α1(I)procollagen expression is decreased by 25%, with maximal reductions (10-fold) seen following 24-120 h of treatment. Similarly, α-smooth muscle actin (αSMA) expression is significantly lower[1]. Deferasirox had anti-proliferative effects on HL-60 or KG-1 myeloid leukemia cell lines at a concentration as low as 5 μM . The cytotoxicity is both dose and time dependent[2]. The viability of both EL4 cells and L1210 cells incubated with deferasirox decrease in a concentration-dependent manner[3]. |
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| In Vivo | The tumor is significantly smaller in the SIO mice treated with deferasirox compared with control. Mice treated with DFX showed longer survival than the other groups. Deferasirox has a survival benefit for SIO leukemia murine model in terms of iron chelation and antileukemic therapy[3]. |
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| Cell Assay | Deferasirox is dissolved in DMSO. HL-60 or KG-1 cells are treated with 0, 5, 10, 50 μM of deferasirox for 24 or 48 h, and proliferation is determined by an MTT assay[2]. |
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| Animal Admin | Mice: Murine leukemia cells are injected subcutaneously into the right flank of mice. Deferasirox is dissolved in distilled water and orally administered at 20 mg/kg until the cumulative dose reaches 300 mg/kg. The mice are observed and weighed daily[3]. |
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| References | [1]. Sobbe A, et al. Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox. J Gastroenterol Hepatol. 2015 Mar;30(3):638-45. [2]. Kim JL, et al. The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targetingcaspase. Acta Haematol. 2011;126(4):241-5. [3]. Lee DH, et al. Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status. Exp Hematol. 2013 Jun;41(6):539-46. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 672.1±65.0 °C at 760 mmHg |
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| Melting Point | 260-262ºC |
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| Molecular Formula | C21H15N3O4 |
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| Molecular Weight | 373.362 |
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| Flash Point | 360.3±34.3 °C |
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| Exact Mass | 373.106262 |
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| PSA | 107.95000 |
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| LogP | 6.43 |
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| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
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| Index of Refraction | 1.699 |
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| InChIKey | BOFQWVMAQOTZIW-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1ccc(-n2nc(-c3ccccc3O)nc2-c2ccccc2O)cc1 |
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| Storage condition | -20°C Freezer |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
