CAS 380843-75-4|Bosutinib (SKI-606)
| Common Name | Bosutinib (SKI-606) | ||
|---|---|---|---|
| CAS Number | 380843-75-4 | Molecular Weight | 530.446 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 649.7±55.0 °C at 760 mmHg |
| Molecular Formula | C26H29Cl2N5O3 | Melting Point | 116-120ºC |
| MSDS | ChineseUSA | Flash Point | 346.7±31.5 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | bosutinib |
|---|---|
| Synonym | More Synonyms |
Bosutinib (SKI-606) BiologicalActivity
| Description | Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively. |
|---|---|
| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>Bcr-AblSignaling Pathways >>Protein Tyrosine Kinase/RTK >>SrcResearch Areas >>Cancer |
| References | [1]. Boschelli DH, et al. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J Med Chem, 2001, 44(23), 3965-3977. [2]. Golas JM, et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res, 2003, 63(2), 375-381. [3]. Vultur A, et al. SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther, 2008, 7(5), 1185-1194. [4]. Golas JM, et al. SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res, 2005, 65(12), 5358-5364. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 649.7±55.0 °C at 760 mmHg |
| Melting Point | 116-120ºC |
| Molecular Formula | C26H29Cl2N5O3 |
| Molecular Weight | 530.446 |
| Flash Point | 346.7±31.5 °C |
| Exact Mass | 529.164734 |
| PSA | 82.88000 |
| LogP | 5.48 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.652 |
| InChIKey | UBPYILGKFZZVDX-UHFFFAOYSA-N |
| SMILES | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl |
| Storage condition | room temp |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319-H413 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
Articles19
More Articles| Src Kinase Is the Connecting Player between Protein Kinase A (PKA) Activation and Hyperpolarization through SLO3 Potassium Channel Regulation in Mouse Sperm. J. Biol. Chem. 290 , 18855-64, (2015) Plasma membrane hyperpolarization is crucial for mammalian sperm to acquire acrosomal responsiveness during capacitation. Among the signaling events leading to mammalian sperm capacitation, the immedi... | |
| In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib. J. Hematol. Oncol. 8 , 81, (2015) Bosutinib is a recently approved ABL inhibitor. In spite of the well-documented effectiveness of BCR-ABL inhibitors in treating chronic myeloid leukemia, development of resistance is a continuous clin... | |
| A simple method for the determination of Bosutinib in rat plasma by UPLC-MS/MS. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1004 , 93-7, (2015) In this work, a simple, sensitive and fast ultra performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantitative determination of b... |
Synonyms
| Bosutinib(SKI 606) |
| 3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]- |
| 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
| SKI 606 |
| SKI-606 |
| Bosutinib |
| Bosutinib for research |
| Bosutinib (SKI-606) |
| T66 BNJ DCN EMR BG DG EO1& HO1 IO3- AT6N DNTJ D1 |
