Introduction：Basic information about CAS 3520-14-7|D-Tetrahydropalmatine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | D-Tetrahydropalmatine |
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| CAS Number | 3520-14-7 | Molecular Weight | 355.427 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 482.9±45.0 °C at 760 mmHg |
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| Molecular Formula | C21H25NO4 | Melting Point | / |
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| MSDS | / | Flash Point | 138.7±25.9 °C |
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Names
| Name | D-Tetrahydropalmatine |
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| Synonym | More Synonyms |
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D-Tetrahydropalmatine BiologicalActivity
| Description | D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis[1]. D-Tetrahydropalmatine is a Dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors[2]. D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor[3]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Metabolic Disease |
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| Target | DA[2], OCT1[3] |
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| References | [1]. Ma ZJ, et al. [Effects of different types and standard of processing vinegaron inherent constituents in rhizoma of Corydalis yanhusuo]. Zhongguo Zhong Yao Za Zhi. 2006 Mar;31(6):465-7. [2]. Xu SX, et al. Effects of tetrahydroprotoberberines on dopamine receptor subtypes in brain. Zhongguo Yao Li Xue Bao. 1989 Mar;10(2):104-10. [3]. Tu M, et al. Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important rolein its hepatotoxicity. Toxicology. 2013 Sep 15;311(3):225-30. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 482.9±45.0 °C at 760 mmHg |
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| Molecular Formula | C21H25NO4 |
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| Molecular Weight | 355.427 |
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| Flash Point | 138.7±25.9 °C |
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| Exact Mass | 355.178345 |
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| PSA | 40.16000 |
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| LogP | 3.70 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.609 |
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| InChIKey | AEQDJSLRWYMAQI-QGZVFWFLSA-N |
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| SMILES | COc1cc2c(cc1OC)C1Cc3ccc(OC)c(OC)c3CN1CC2 |
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Safety Information
Synonyms
| 6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aS)- |
| levo-tetrahydropalmatine |
| 6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aR)- |
| (S)-tetrahydropalmatine |
| (13aS)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline |
| Tetrahydropalmatine |
| (+)-Tetrahydropalmatine |
| (13aS)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline |
| d-Tetrahydropalmatine |
| l-Tetrahydropalmatine |
| (-)-Tetrahydropalmatine |
| (R)-(+)-tetrahydropalmatine |
| D-Tetrahydropalmatin |
| (13aR)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline |
