CAS 123653-11-2|NS-398
| Common Name | NS-398 | ||
|---|---|---|---|
| CAS Number | 123653-11-2 | Molecular Weight | 314.357 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 490.6±55.0 °C at 760 mmHg |
| Molecular Formula | C13H18N2O5S | Melting Point | 139 °C |
| MSDS | ChineseUSA | Flash Point | 250.5±31.5 °C |
Names
| Name | NS398 |
|---|---|
| Synonym | More Synonyms |
NS-398 BiologicalActivity
| Description | NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>COXResearch Areas >>Inflammation/Immunology |
| Target | COX-2:3.8 μM (IC50) |
| In Vitro | NS-398 is a non-steroidal an-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM[1]. NS-398 weakly inhibits PG endoperoxide synthase activity from sheep seminal vesicle microsomes (IC50, 11 μM)[2]. |
| In Vivo | NS-398 (0.5-10 mg/kg, p.o.) dose-dependently inhibits paw edema in rats, with an ED30 of 1.14 mg/kg, shows therapeutic effects on adjuvant arthritis (ED30, 4.69 mg/kg), exhibits dose-dependent analgesic activity (ED50, 1.65 mg/kg), and has antipyretic effect (ED50, 1.84 mg/kg) in rats. In mice, NS-398 suppresses writhing reactions induced by acetic acid with an ED50 of 8.2 mg/kg[2]. |
| Animal Admin | Mice[2] Briefly, male ddy mice weighing about 30 g are used. The writhing syndrome is induced by injecting 0.75% of acetic acid, intraperitoneally. Ten minutes later, the number of writhings are counted for the next 10 min. NS-398 is administered orally 30 min prior to the injection. The analgesic effect is expressed as % of inhibition, compared with the vehicle-treated control[2]. Rats[2] Briefly, male Lewis rats weighing about 160 g are used. Arthritis is induced by injecting 0.1 mL of 0.7% Mycobacterium tubercu-losis-liquid paraffin into the left hind paw. On day 15, the rats are grouped according to the degree of secondary lesions in the right hind paw. NS-398 is administered orally once daily from days 15 to 18. Foot volume is measured on day 19. Relative edema volume (REV) is calculated for each animal[2]. |
| References | [1]. Futaki N, et al. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 1994 Jan;47(1):55-9. [2]. Futaki N, et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol. 1993 Jan;24(1):105-10. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 490.6±55.0 °C at 760 mmHg |
| Melting Point | 139 °C |
| Molecular Formula | C13H18N2O5S |
| Molecular Weight | 314.357 |
| Flash Point | 250.5±31.5 °C |
| Exact Mass | 314.093628 |
| PSA | 109.60000 |
| LogP | 3.67 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.593 |
| InChIKey | KTDZCOWXCWUPEO-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1OC1CCCCC1 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 3824909990 |
Customs
| HS Code | 3824909990 |
|---|
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Synonyms
| MFCD00882995 |
| Methanesulfonamide, N-[2-(cyclohexyloxy)-4-nitrophenyl]- |
| N-(2-Cyclohexyloxy-4-nitro-phenyl)-; methanesulfonamide |
| NS-398 |
| Potassium Chloride |
| N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide |
