CAS 153-18-4|Rutin

Introduction：Basic information about CAS 153-18-4|Rutin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Rutin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Rutin
CAS Number	153-18-4	Molecular Weight	610.518
Density	1.8±0.1 g/cm3	Boiling Point	983.1±65.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₀O₁₆	Melting Point	195 °C (dec.)(lit.)
MSDS	/	Flash Point	325.4±27.8 °C

Names

Name	rutin
Synonym	More Synonyms

Rutin BiologicalActivity

Description	Rutin, a naturally occurring flavonoid glycoside, has antioxidant, anti-inflammatory, anti-allergic, anti-angiogenic and antiviral properties.
Related Catalog	Signaling Pathways >>Autophagy >>AutophagyNatural Products >>FlavonoidsResearch Areas >>Inflammation/Immunology
References	[1]. E. H. Aksu, et al. Rutin ameliorates cisplatin-induced reproductive damagevia suppression of oxidative stress and apoptosis in adultmale rats. Andrologia. 2016 Apr 23. [2]. Han YH, et al. Lipin1-Mediated Repression of Adipogenesis by Rutin.Am J Chin Med. 2016;44(3):565-78 [3]. Lu N, et al. Effects of rutin on the redox reactions of hemoglobin. Int J Biol Macromol. 2016 Apr 25;89:175-180.

Description

Rutin, a naturally occurring flavonoid glycoside, has antioxidant, anti-inflammatory, anti-allergic, anti-angiogenic and antiviral properties.

Related Catalog

Signaling Pathways >>Autophagy >>AutophagyNatural Products >>FlavonoidsResearch Areas >>Inflammation/Immunology

References

[1]. E. H. Aksu, et al. Rutin ameliorates cisplatin-induced reproductive damagevia suppression of oxidative stress and apoptosis in adultmale rats. Andrologia. 2016 Apr 23.

[2]. Han YH, et al. Lipin1-Mediated Repression of Adipogenesis by Rutin.Am J Chin Med. 2016;44(3):565-78

[3]. Lu N, et al. Effects of rutin on the redox reactions of hemoglobin. Int J Biol Macromol. 2016 Apr 25;89:175-180.

Chemical & Physical Properties

Density	1.8±0.1 g/cm3
Boiling Point	983.1±65.0 °C at 760 mmHg
Melting Point	195 °C (dec.)(lit.)
Molecular Formula	C₂₇H₃₀O₁₆
Molecular Weight	610.518
Flash Point	325.4±27.8 °C
Exact Mass	610.153381
PSA	269.43000
LogP	1.76
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.765
InChIKey	IKGXIBQEEMLURG-NVPNHPEKSA-N
SMILES	CC1OC(OCC2OC(Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)C(O)C(O)C2O)C(O)C(O)C1O
Storage condition	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Water Solubility	12.5 g/100 mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VM2975000

CHEMICAL NAME :: Rutin

CAS REGISTRY NUMBER :: 153-18-4

BEILSTEIN REFERENCE NO. :: 0075455

LAST UPDATED :: 199701

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C27-H30-O16

MOLECULAR WEIGHT :: 610.57

WISWESSER LINE NOTATION :: T66 BO EVJ CR CQ DQ& GQ IQ DO- BT6OTJ CQ DQ EQ F1O- BT6OTJ CQ DQ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 973 gm/kg/3Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Body fluid assay

TEST SYSTEM :: Rodent - rat Bacteria - Salmonella typhimurium

DOSE/DURATION :: 2 gm/kg

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 25,9,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80506 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80506 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 934 (estimated) No. of Female Employees: 506 (estimated)

Safety Information

Hazard Codes	Xn: Harmful;Xi: Irritant;
Risk Phrases	R22
Safety Phrases	S24/25
WGK Germany	3
RTECS	VM2975000
HS Code	2932999099

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-one

4H-1-Benzopyran-4-one, 3-((6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-

Tanrutin

4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-

Quercetin 3-O-β-D-rutinoside

3,3',4',5,7-Pentahydroxyflavone 3-(O-rhamnosylglucoside)

Venoruton

Vitamin P trihydrate

Ilixathin

Quercetin 3-O-rutinoside

Quercetin 3-β-rutinoside

Rutinion acid

Osyritrin

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl-6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

3-((6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one

Violaquercitrin

Rutozyd

EINECS 205-814-1

Globularicitrin

Sophorin

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-mannopyranoside

Paliuroside

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

Eldrin

Rutabion

Rutin hydrate

Oxyritin

Rutoside

Quercetin 3-O-β-rutinoside

Rutin

Rutin trihydrate

3-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one

3,3',4',5,7-Pentahydroxyflavone-3-rutinoside

Birutan

4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-

Melin

Osyritin

Rutinic acid

Quercetin-3-O-rutinoside

MFCD00006830

Myrticolorin

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