CAS 3878-19-1|Fuberidazole
Introduction：Basic information about CAS 3878-19-1|Fuberidazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fuberidazole | ||
|---|---|---|---|
| CAS Number | 3878-19-1 | Molecular Weight | 184.19 |
| Density | 1.286g/cm3 | Boiling Point | 380.6ºC at 760 mmHg |
| Molecular Formula | C11H8N2O | Melting Point | 310-312℃ |
| MSDS | ChineseUSA | Flash Point | 194.7ºC |
| Symbol | GHS06, GHS08, GHS09 | Signal Word | Danger |
Names
| Name | fuberidazole |
|---|---|
| Synonym | More Synonyms |
Fuberidazole BiologicalActivity
| Description | Fuberidazole (BAY 33172; Furidazole) is a fungicide. Fuberidazole shows a synergistic effect with cucurbituril (CB) macromolecules, such as CB7 and CB8. Studies have shown that, CB8 induces pKa shifts on Fuberidazole. Fuberidazole significantly inhibits the growth of B. cinerea[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal |
| Target | B. cinerea[1] |
| In Vitro | Fuberidazole (FBZ) (10 μM) 在 CB8 (100 μM) 存在的情况下表现出 1.4 个单位的 pKa 偏移[1]。 Fuberidazole (10-200 μM; 72 h) 对灰霉病菌 (B. cinerea) 表现出增加的生长抑制率。与 CB7/CB8 结合的 Fuberidazole 对 B. cinerea 的生长至少是 Fuberidazole 单独抑制 3 倍[1]。 |
| References | [1]. Saleh N, et al. Enhancement of in vitro fungicidal activity of fuberidazole to Botrytis cinerea by cucurbiturils. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2014, 79: 301-309. |
Chemical & Physical Properties
| Density | 1.286g/cm3 |
|---|---|
| Boiling Point | 380.6ºC at 760 mmHg |
| Melting Point | 310-312℃ |
| Molecular Formula | C11H8N2O |
| Molecular Weight | 184.19 |
| Flash Point | 194.7ºC |
| Exact Mass | 184.06400 |
| PSA | 41.82000 |
| LogP | 2.82290 |
| Index of Refraction | 1.67 |
| InChIKey | UYJUZNLFJAWNEZ-UHFFFAOYSA-N |
| SMILES | c1coc(-c2nc3ccccc3[nH]2)c1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 330 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 825 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 15,273,1972 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,151,1975
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 15,273,1972 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,151,1975
Safety Information
| Symbol | GHS06, GHS08, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H311-H317-H330-H351-H373-H410 |
| Precautionary Statements | P260-P273-P280-P284-P304 + P340 + P310-P403 + P233 |
| Target Organs | Heart |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn,N |
| Risk Phrases | R22:Harmful if swallowed. R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . |
| Safety Phrases | S22-S60-S61 |
| RIDADR | 2588 |
| WGK Germany | 3.0 |
| RTECS | DD9010000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Fubridazole |
| EINECS 223-404-0 |
| 2-(2-Furanyl)-1H-benzimidazole |
| 2-(furan-2-yl)-benzimidazole |
| 2-(furan-2-yl)-1H-benzo[d]imidazole |
| Benzimidazole,2-(2-furyl) |
| 2-(furan-2-yl)-1H-benzimidazole |
| Fuberidatol |
| 2-(2'-furyl)-benzimidazole |
| Voronite |
| Fuberidazol |
| Furidazole |
| Furidazol |
| MFCD00055496 |
| 2-(2-furyl)benzimidazole |
| Fuberisazol |
| 2-(furan-2-yl)-1H-1,3-benzimidazole |
| 2-(2'-furyl)-1H-benzimidazole |
| Voronit |
