CAS 1119-34-2|L-Arginine hydrochloride
Introduction：Basic information about CAS 1119-34-2|L-Arginine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-Arginine hydrochloride | ||
|---|---|---|---|
| CAS Number | 1119-34-2 | Molecular Weight | 210.662 |
| Density | 1.42 | Boiling Point | 409.1ºC at 760 mmHg |
| Molecular Formula | C6H15ClN4O2 | Melting Point | 226-230 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 201.2ºC |
Names
| Name | 2-Amino-5-guanidinovaleric acid monohydrochloride |
|---|---|
| Synonym | More Synonyms |
L-Arginine hydrochloride BiologicalActivity
| Description | L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersArginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>OthersNatural Products >>Others |
| References | [1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45. [2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12. [3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17. |
Chemical & Physical Properties
| Density | 1.42 |
|---|---|
| Boiling Point | 409.1ºC at 760 mmHg |
| Melting Point | 226-230 °C(lit.) |
| Molecular Formula | C6H15ClN4O2 |
| Molecular Weight | 210.662 |
| Flash Point | 201.2ºC |
| Exact Mass | 210.088348 |
| PSA | 125.22000 |
| LogP | 1.35480 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12 gm/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,49,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3793 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 58,253,1955 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 90 mg/kg
- SEX/DURATION :
- female 1-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 51,553,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81859 No. of Facilities: 86 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 857 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81859 No. of Facilities: 585 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 5477 (estimated) No. of Female Employees: 2954 (estimated)
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S37/39-S26-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | CF1995500 |
| HS Code | 2922499990 |
Customs
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| (+)-L-arginine hydrochloride |
| Arginine, hydrochloride, L- |
| (2S)-2-amino-5-carbamimidamidopentanoic acid hydrochloride |
| levargin |
| L-Arginine HCl |
| L-(+)-Arginine monohydrochloride |
| L-Arginine hydrochloride |
| L-ARG HCL |
| (S)-2-Amino-5-guanidinopentanoic acid hydrochloride |
| (S)-(+)-Arginine hydrochloride,L-Arginine hydrochloride |
| L-Arginine hydrochloride (1:1) |
| (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride |
| 2-Amino-5-guanidinovalericacidmonohydrochloride |
| anhydrous L-arginine monohydrochloride |
| L-Arginine HCl (L-Arg) |
| Arginine hydrochloride |
| L-Arginine.HCl |
| Arginine Muriate |
| S-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride |
| (S)-arginine hydrochloride |
| L(+)-Arginine hydrochloride |
| ARG,HCL |
| (2S)-2-Amino-5-carbamimidamidopentansäurehydrochlorid |
| L-Arginine, hydrochloride (1:1) |
| EINECS 214-275-1 |
| L-Arginine Monohydrochloride (VAN) |
| 2-Amino-5-guanidinovaleric ac |
| detoxargin |
| r-gene |
| Arginine HCL |
| argivene |
| MFCD00064550 |
| H-Arg-OH.HCl |
| L-arginine, hydrochloride |
| acide (2S)-2-amino-5-carbamimidamidopentanoïque chlorhydrate |
| L-Arginine monohydrochloride |
| minophagena |
| L-Arginine (hydrochloride) |
