CAS 5741-22-0|1-(ISOPROPYLAMINO)-3-(2-METHOXYPHENOXY)PROPAN-2-OL
Introduction：Basic information about CAS 5741-22-0|1-(ISOPROPYLAMINO)-3-(2-METHOXYPHENOXY)PROPAN-2-OL, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-(ISOPROPYLAMINO)-3-(2-METHOXYPHENOXY)PROPAN-2-OL | ||
|---|---|---|---|
| CAS Number | 5741-22-0 | Molecular Weight | 239.31 |
| Density | 1.054g/cm3 | Boiling Point | 379.2ºC at 760mmHg |
| Molecular Formula | C13H21NO3 | Melting Point | / |
| MSDS | / | Flash Point | 183.2ºC |
Names
| Name | moprolol |
|---|
BiologicalActivity
| Description | Moprolol ((±)-Moprolol) is an beta-adrenergic receptor blocker, which can be used for research in essential hypertension[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
| Target | Beta-1 adrenergic receptor |
| In Vitro | l-Moprolol 是一种 β 阻断剂的 l-对映体，具有低负性肌力活性和轻度内在拟交感神经活性，可有效用于全身性高血压研究。在原发性开角型青光眼 (POAG) 或高眼压 (OHT) 模型中，局部应用l-Moprolol 可与噻洛尔一样有效地降低眼压 (IOP)，由于其对支气管肌肉缺乏活性，已成为抑制青光眼的一种很有前景的化合物[3]。 |
| References | [1]. Borowiecki P, et al. Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol. RSC Adv. 2022 Aug 10;12(34):22150-22160. [2]. Liu J, et al. beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension. Clin Pharmacol Ther. 2006 Jul;80(1):23-32. [3]. Rossetti L, et al. The efficacy of the combination of l-moprolol and dipivefrin in reducing the intraocular pressure in primary open-angle glaucoma or in ocular hypertension. Graefes Arch Clin Exp Ophthalmol. 1994 Nov;232(11):670-4. |
Chemical & Physical Properties
| Density | 1.054g/cm3 |
|---|---|
| Boiling Point | 379.2ºC at 760mmHg |
| Molecular Formula | C13H21NO3 |
| Molecular Weight | 239.31 |
| Flash Point | 183.2ºC |
| Exact Mass | 239.15200 |
| PSA | 50.72000 |
| LogP | 1.82380 |
| Index of Refraction | 1.509 |
| InChIKey | LFTFGCDECFPSQD-UHFFFAOYSA-N |
| SMILES | COc1ccccc1OCC(O)CNC(C)C |
