CAS 70359-46-5|Brimonidine L-tartrate

Introduction：Basic information about CAS 70359-46-5|Brimonidine L-tartrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Brimonidine L-tartrate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles33
7. Synonyms

Common Name	Brimonidine L-tartrate
CAS Number	70359-46-5	Molecular Weight	442.221
Density	/	Boiling Point	432.6ºC at 760 mmHg
Molecular Formula	C₁₅H₁₆BrN₅O₆	Melting Point	207-208ºC (dec.)
MSDS	/	Flash Point	215.4ºC
Symbol	GHS06	Signal Word	Danger

Names

Name	5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)-6-Quinoxalinamine Tartrate
Synonym	More Synonyms

Brimonidine L-tartrate BiologicalActivity

Description	UK 14,304 is a full α2-adrenergic receptor (α2-AR) agonist.Target: α2-adrenergic Receptor[3H]UK 14,034 is a full agonist at alpha 2-adrenergic receptors. [3H]UK 14,304 labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Others
References	[1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12. [2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5. [3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804.

Description

UK 14,304 is a full α2-adrenergic receptor (α2-AR) agonist.Target: α2-adrenergic Receptor[3H]UK 14,034 is a full agonist at alpha 2-adrenergic receptors. [3H]UK 14,304 labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Others

References

[1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12.

[2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5.

[3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804.

Chemical & Physical Properties

Boiling Point	432.6ºC at 760 mmHg
Melting Point	207-208ºC (dec.)
Molecular Formula	C₁₅H₁₆BrN₅O₆
Molecular Weight	442.221
Flash Point	215.4ºC
Exact Mass	441.028381
PSA	177.26000
InChIKey	QZHBYNSSDLTCRG-LREBCSMRSA-N
SMILES	Brc1c(NC2=NCCN2)ccc2nccnc12.O=C(O)C(O)C(O)C(=O)O
Storage condition	-20°C Freezer

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335
Precautionary Statements	Missing Phrase - N15.00950417-P305 + P351 + P338
Safety Phrases	S36/37
RIDADR	UN 2811 6.1 / PGIII
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles33

Dilute brimonidine to improve patient comfort and subconjunctival hemorrhage after LASIK.

J. Refract. Surg. 29(7) , 469-75, (2013)

To investigate whether dilute brimonidine (0.025%) reduces patient discomfort, subconjunctival hemorrhage, and injection after LASIK without a significant increase in the rate of flap complications or...

Targeted delivery of antiglaucoma drugs to the supraciliary space using microneedles.

Invest. Ophthalmol. Vis. Sci. 55(11) , 7387-97, (2014)

In this work, we tested the hypothesis that highly targeted delivery of antiglaucoma drugs to the supraciliary space by using a hollow microneedle allows dramatic dose sparing of the drug compared to ...

Determinants and characteristics of angle-closure disease in an elderly Chinese population.

Ophthalmic Epidemiol. 22(2) , 109-15, (2015)

To determine factors associated with angle-closure disease, particularly in those with structural or functional damage to the eyes, in an elderly Chinese population.A total of 460 individuals aged ove...

Synonyms

Brimonidine tartrate

5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl) quinoxalin-6-amine tartrate

(2R,3R)-2,3-Dihydroxysuccinic acid - 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine (1:1)

5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine L-tartrate

5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, (2R,3R)-2,3-dihydroxybutanedioate

Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine (1:1)

MFCD07773086

UK 14,304 (tartrate)

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