CAS 127-56-0|Sulfacetamide sodium

Introduction：Basic information about CAS 127-56-0|Sulfacetamide sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sulfacetamide sodium BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Sulfacetamide sodium
CAS Number	127-56-0	Molecular Weight	236.223
Density	/	Boiling Point	450.8ºC at 760 mmHg
Molecular Formula	C₈H₉N₂NaO₃S	Melting Point	/
MSDS	ChineseUSA	Flash Point	226.4ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	sulfacetamide sodium anhydrous
Synonym	More Synonyms

Sulfacetamide sodium BiologicalActivity

Description	Sulfacetamide Sodium is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.Target: AntibacterialSulfacetamide is a sulfonamide antibiotic. Sulfacetamide is able to inhibit the growth of all isolated strains. Depending on the type of bacteria concentrations of 0.006 up to 6.4% sodium sulfacetamide proved to be effective. Simultaneously, all patients were treated with sulfacetamide containing ointment and/or eye drops 4 times daily for maximum of 14 days. With swabs taken at intervals of 7 and 14 days no bacterial growth was detected. Sulfacetamide 10% topical lotion, sold under the brand name Klaron or Ovace, is approved for the treatment of acne and seborrheic dermatitis. Sulfacetamide has been investigated for use in the treatment of pityriasis versicolor and rosacea. It may also have anti-inflammatory properties when used to treat blepharitis or conjunctivitis. It is believed to work by limiting the presence of folic acid which bacteria need to survive. It has been suggested that sulfacetamide may also serve as a treatment for mild forms of hidradenitis suppurativa. Sulfacetamide has antibacterial activity and is used to control acne. Some research indicates that sulfacetamide derivatives may act as antifungals by an CYP51A1-independent mechanism [1-4].
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection
References	[1]. Del Rosso, J.Q., Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis, 2004. 73(1 Suppl): p. 29-33. [2]. Mastrolorenzo, A. and C.T. Supuran, Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs, 2000. 7(1): p. 49-54. [3]. http://www.drugs.com/mtm/klaron.html [4]. Roth, H.W., et al., [The effective antibacterial spectrum of sulfacetamide]. Klin Monbl Augenheilkd, 1992. 200(3): p. 182-6.

Description

Sulfacetamide Sodium is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.Target: AntibacterialSulfacetamide is a sulfonamide antibiotic. Sulfacetamide is able to inhibit the growth of all isolated strains. Depending on the type of bacteria concentrations of 0.006 up to 6.4% sodium sulfacetamide proved to be effective. Simultaneously, all patients were treated with sulfacetamide containing ointment and/or eye drops 4 times daily for maximum of 14 days. With swabs taken at intervals of 7 and 14 days no bacterial growth was detected. Sulfacetamide 10% topical lotion, sold under the brand name Klaron or Ovace, is approved for the treatment of acne and seborrheic dermatitis. Sulfacetamide has been investigated for use in the treatment of pityriasis versicolor and rosacea. It may also have anti-inflammatory properties when used to treat blepharitis or conjunctivitis. It is believed to work by limiting the presence of folic acid which bacteria need to survive. It has been suggested that sulfacetamide may also serve as a treatment for mild forms of hidradenitis suppurativa. Sulfacetamide has antibacterial activity and is used to control acne. Some research indicates that sulfacetamide derivatives may act as antifungals by an CYP51A1-independent mechanism [1-4].

Related Catalog

Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection

References

[1]. Del Rosso, J.Q., Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis, 2004. 73(1 Suppl): p. 29-33.

[2]. Mastrolorenzo, A. and C.T. Supuran, Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs, 2000. 7(1): p. 49-54.

[3]. http://www.drugs.com/mtm/klaron.html

[4]. Roth, H.W., et al., [The effective antibacterial spectrum of sulfacetamide]. Klin Monbl Augenheilkd, 1992. 200(3): p. 182-6.

Chemical & Physical Properties

Boiling Point	450.8ºC at 760 mmHg
Molecular Formula	C₈H₉N₂NaO₃S
Molecular Weight	236.223
Flash Point	226.4ºC
Exact Mass	236.023163
PSA	88.85000
LogP	1.93230
InChIKey	PQMSFAORUFMASU-UHFFFAOYSA-M
SMILES	CC(=O)[N-]S(=O)(=O)c1ccc(N)cc1.[Na+]

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC8480000

CHEMICAL NAME :: Acetamide, N-sulfanilyl-, monosodium salt

CAS REGISTRY NUMBER :: 127-56-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H9-N2-O3-S.Na

MOLECULAR WEIGHT :: 236.24

WISWESSER LINE NOTATION :: ZR DSWMV1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 5 ppm

REFERENCE :: RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued. Volume(issue)/page/year: 6,161,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83071 No. of Facilities: 176 (estimated) No. of Industries: 5 No. of Occupations: 4 No. of Employees: 500 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83071 No. of Facilities: 185 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 6788 (estimated) No. of Female Employees: 3730 (estimated)

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	UN 3249
WGK Germany	3
RTECS	AC8480000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2924299090

Customs

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

Sulfacetamide sodium salt

Sodium acetyl[(4-aminophenyl)sulfonyl]azanide

UNII-30760ZE777

Sulfacetamide sodium anhydrous

Sulfacetamide sodium

acetamide, N-[(4-aminophenyl)sulfonyl]-, monosodium salt

SODIUM SULFACETAMIDE

Sulf 10

MFCD00149555

Acetamide, N-[(4-aminophenyl)sulfonyl]-, sodium salt (1:1)

N-Acetylsulfanilamide Sodium Salt Hydrate

Sodium N-sulfanilylacetamide

SULPHACETAMIDE SODIUM

N-Acetyl-4-aminobenzenesulfonamide Sodium Salt Hydrate

sodium,acetyl-(4-aminophenyl)sulfonylazanide

EINECS 204-848-4

SulfacetaMide SodiuM Salt Hydrate

Sulfacetamide (Sodium)

Recommended......