CAS 84-89-9|1-naphthylamine-5-sulfonic acid

Introduction：Basic information about CAS 84-89-9|1-naphthylamine-5-sulfonic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles13
7. Synonyms

Common Name	1-naphthylamine-5-sulfonic acid
CAS Number	84-89-9	Molecular Weight	223.248
Density	1.5±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₁₀H₉NO₃S	Melting Point	>300°C
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS05, GHS07	Signal Word	Danger

Names

Name	5-Aminonaphthalene-1-sulfonic acid
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Melting Point	>300°C
Molecular Formula	C₁₀H₉NO₃S
Molecular Weight	223.248
Exact Mass	223.030319
PSA	88.77000
LogP	0.42
Index of Refraction	1.713
InChIKey	DQNAQOYOSRJXFZ-UHFFFAOYSA-N
SMILES	Nc1cccc2c(S(=O)(=O)O)cccc12

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK1270500

CHEMICAL NAME :: 1-Naphthalenesulfonic acid, 5-amino-

CAS REGISTRY NUMBER :: 84-89-9

BEILSTEIN REFERENCE NO. :: 2214149

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H9-N-O3-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - muscle weakness

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),87,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2880 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),87,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - muscle weakness

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),87,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2990 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),87,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 gm/kg/30D-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - liver function tests impaired Blood - pigmented or nucleated red blood cells

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),87,1986

Safety Information

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H312-H314-H332
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C:Corrosive;
Risk Phrases	R20/21/22;R34
Safety Phrases	S26-S36/37/39-S45
RIDADR	UN 2585 8/PG 3
WGK Germany	3
RTECS	QK1270500
Packaging Group	III
Hazard Class	8
HS Code	2921450090

Customs

HS Code	2921450090
Summary	2921450090 1-naphthylamine (α-naphthylamine), 2-naphthylamine (β-naphthylamine) and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles13

Identification of a novel ligand binding motif in the transthyretin channel.

Bioorg. Med. Chem. 18 , 100-10, (2010)

The design of therapeutic compounds targeting transthyretin (TTR) is challenging due to the low specificity of interaction in the hormone binding site. Such feature is highlighted by the interactions ...

[An interesting peroxidase staining.--utilization of blended substrate of mixed 2, 7-FDA and Laurent's acid-- (author's transl)].

Rinsho Byori. 29(6) , 613-6, (1981)

Evidence for a ppGpp-binding site on Escherichia coli RNA polymerase: proximity relationship with the rifampicin-binding domain.

Mol. Microbiol. 15(2) , 255-65, (1995)

On amino acid starvation, Escherichia coli cells exhibit an adaptive facility termed the stringent response. This is characterized by the production of high levels of a regulatory nucleotide, ppGpp, a...

Synonyms

1-naphthylamine-5-sulfonic acid

5-Amino-1-naphthalenesulfonic acid

5-Aminonaphthalene-1-sulfonic acid

MFCD00014315

1-Naphthalenesulfonic acid, 5-amino-

EINECS 201-571-0

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