CAS 19408-84-5|Dihydrocapsaicin

Introduction：Basic information about CAS 19408-84-5|Dihydrocapsaicin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dihydrocapsaicin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles34
8. Synonyms

Common Name	Dihydrocapsaicin
CAS Number	19408-84-5	Molecular Weight	307.428
Density	1.0±0.1 g/cm3	Boiling Point	457.3±55.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₉NO₃	Melting Point	62-65 °C(lit.)
MSDS	ChineseUSA	Flash Point	230.4±31.5 °C
Symbol	GHS06	Signal Word	Danger

Names

Name	dihydrocapsaicin
Synonym	More Synonyms

Dihydrocapsaicin BiologicalActivity

Description	Dihydrocapsaicin is a natural capsaicin, acts as a selective TRPV1 agonist, and also increases p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection[1][2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP Channel
References	[1]. Gao F, et al. Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism. Hypertension. 2010 Apr;55(4):1018-25. [2]. Dihydrocapsaicin, et al. Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat. Brain Res. 2017 Sep 15;1671:18-25.

Description

Dihydrocapsaicin is a natural capsaicin, acts as a selective TRPV1 agonist, and also increases p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection[1][2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP Channel

References

[1]. Gao F, et al. Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism. Hypertension. 2010 Apr;55(4):1018-25.

[2]. Dihydrocapsaicin, et al. Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat. Brain Res. 2017 Sep 15;1671:18-25.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	457.3±55.0 °C at 760 mmHg
Melting Point	62-65 °C(lit.)
Molecular Formula	C₁₈H₂₉NO₃
Molecular Weight	307.428
Flash Point	230.4±31.5 °C
Exact Mass	307.214752
PSA	58.56000
LogP	4.72
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.508
InChIKey	XJQPQKLURWNAAH-UHFFFAOYSA-N
SMILES	COc1cc(CNC(=O)CCCCCCC(C)C)ccc1O
Storage condition	2-8°C
Water Solubility	H2O: insoluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RA5998000

CHEMICAL NAME :: Nonanamide, 8-methyl-N-vanillyl-

CAS REGISTRY NUMBER :: 19408-84-5

BEILSTEIN REFERENCE NO. :: 2815150

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H29-N-O3

MOLECULAR WEIGHT :: 307.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 5 mg/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 48,109,1989

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R25;R36/37/38
Safety Phrases	S22-S26-S28-S36/39-S45-S36/37/39
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	RA8530000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	3302109090

Customs

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles34

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves.

Life Sci. 92(6-7) , 368-78, (2013)

Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined. The purpose of th...

Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.

J. Pharm. Biomed. Anal. 60 , 51-8, (2012)

Capsaicinoids, salicylic acid, methyl and ethyl salicylate, glycol monosalicylate, camphor and l-menthol are widely used in topical formulations to relieve local pain. For each separate compound or si...

Synonyms

N-(4-Hydroxy-3-methoxybenzyl)-8-methylnonanamide

Nonanimidic acid, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (1Z)-

(1Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnonanimidic acid

6,7-Dihydrocapsaicin

8-methyl-nonanoic acid vanillylamide

N-[(4-Hydroxy-3-methoxy-phenyl)methyl]-8-methyl-nonanamide

Nonanamide,8-methyl-N-vanillyl

Dihydro Capsaicin

MFCD00017259

N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnonanamide

Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-

8-Methyl-N-vanillyl-nonamide

Dihydrocapsaicin

Nonanamide, 8-methyl-N-vanillyl-

EINECS 206-969-8

8-Methyl-N-vanillylnonanamide

N-(4-hydroxy-3-methoxybenzyl)isodecanamide

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