CAS 67-45-8|Furazolidone

Introduction：Basic information about CAS 67-45-8|Furazolidone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Furazolidone BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles52
8. Synonyms

Common Name	Furazolidone
CAS Number	67-45-8	Molecular Weight	225.158
Density	1.7±0.1 g/cm3	Boiling Point	353.4±52.0 °C at 760 mmHg
Molecular Formula	C₈H₇N₃O₅	Melting Point	254-256ºC (dec.)
MSDS	ChineseUSA	Flash Point	167.5±30.7 °C
Symbol	GHS08	Signal Word	Warning

Names

Name	furazolidone
Synonym	More Synonyms

Furazolidone BiologicalActivity

Description	Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Target: Antibacterial Furazolidone is a novel therapeutic strategy in AML patients. Furazolidone can Inhibit the bone-marrow transformation mediated by a series of leukemia fusion proteins. Furazolidone significantly inhibits proliferation of AML cell lines. Furazolidone induces apoptosis of the AML leukemic cells treatment with Furazolidone induces differentiation of AML cell lines.
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection
References	[1]. Jiang X, et al. A novel application of furazolidone: anti-leukemic activity in acute myeloid leukemia. PLoS One. 2013 Aug 9;8(8):e72335.

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Boiling Point	353.4±52.0 °C at 760 mmHg
Melting Point	254-256ºC (dec.)
Molecular Formula	C₈H₇N₃O₅
Molecular Weight	225.158
Flash Point	167.5±30.7 °C
Exact Mass	225.038574
PSA	100.86000
LogP	-0.49
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.670
InChIKey	PLHJDBGFXBMTGZ-UITAMQMPSA-N
SMILES	O=C1OCCN1N=Cc1ccc([N+](=O)[O-])o1
Storage condition	0-6°C
Water Solubility	formic acid: soluble50mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ3675000

CHEMICAL NAME :: 2-Oxazolidinone, 3-((5-nitrofurfurylidene)amino)-

CAS REGISTRY NUMBER :: 67-45-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 49

MOLECULAR FORMULA :: C8-H7-N3-O5

MOLECULAR WEIGHT :: 225.18

WISWESSER LINE NOTATION :: T5OJ BNW E1UN- AT5NVOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression Blood - eosinophilia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2336 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1782 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 700 mg/kg

SEX/DURATION :: male 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 840 mg/kg

SEX/DURATION :: male 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Mammal - domestic Leukocyte

DOSE/DURATION :: 50 ug/L

REFERENCE :: RVMVAH Revue de Medecine Veterinaire (Toulouse). (Ecole Nationale Veterinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France) V.89(2)- 1937- Volume(issue)/page/year: 126,1611,1975 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,141,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,141,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84610 No. of Facilities: 258 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 3165 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84610 No. of Facilities: 1628 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 16392 (estimated) No. of Female Employees: 2949 (estimated)

Safety Information

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H361
Precautionary Statements	P281
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn:Harmful
Risk Phrases	R62
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RQ3675000
HS Code	2934992000

Customs

HS Code	2934992000

Articles52

Beneficial effects of intramyocardial mesenchymal stem cells and VEGF165 plasmid injection in rats with furazolidone induced dilated cardiomyopathy.

J. Cell. Mol. Med. 19 , 1868-76, (2015)

To explore the impact of myocardial injection of mesenchymal stem cells (MSCs) and specific recombinant human VEGF165 (hVEGF165 ) plasmid on collagen remodelling in rats with furazolidone induced dila...

Novel UV-spectrophotometric method for quantitative estimation of furazolidone using mixed hydrotropic agent.

Pak. J. Pharm. Sci. 26(1) , 159-62, (2013)

A novel, eco friendly, accurate, sensitive, economic and safe spectrophotometric method was developed by application of mixed hydrotropy using 2 M sodium acetate, 8 M urea, 2 M niacinamide and 2 M sod...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Synonyms

2-Oxazolidinone, 3-[[(1E)-(5-nitro-2-furanyl)methylene]amino]-

Furall

Bifuron

MFCD00010550

3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone

3-{(E)-[(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one

3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone

Furidon

Furazolidone

3-{[(E)-(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one

Neftin

nf-180

Furazon

Furazol

Furaxon

Furox

3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone

EINECS 200-653-3

Recommended......