Introduction：Basic information about CAS 559-74-0|Friedelin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Friedelin |
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| CAS Number | 559-74-0 | Molecular Weight | 426.717 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 477.2±13.0 °C at 760 mmHg |
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| Molecular Formula | C30H50O | Melting Point | 262-265ºC(lit.) |
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| MSDS | ChineseUSA | Flash Point | 233.9±12.1 °C |
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Names
| Name | friedelin |
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| Synonym | More Synonyms |
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Friedelin BiologicalActivity
| Description | Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54 μM and 18.02 μM, respectively[1]. |
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| Related Catalog | Research Areas >>Others |
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| Target | IC50: 10.79 μM (CYP3A4), 22.54 μM (CYP2E1); Ki: 6.16 μM(CYP3A4), 18.02 μM(CYP2E1)[1] |
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| References | [1]. Wei J, et al. In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes. Pharm Biol. 2018 Dec;56(1):363-367. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 477.2±13.0 °C at 760 mmHg |
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| Melting Point | 262-265ºC(lit.) |
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| Molecular Formula | C30H50O |
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| Molecular Weight | 426.717 |
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| Flash Point | 233.9±12.1 °C |
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| Exact Mass | 426.386169 |
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| PSA | 17.07000 |
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| LogP | 10.87 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.503 |
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| InChIKey | OFMXGFHWLZPCFL-SVRPQWSVSA-N |
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| SMILES | CC1C(=O)CCC2C1(C)CCC1C2(C)CCC2(C)C3CC(C)(C)CCC3(C)CCC12C |
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| Storage condition | 2-8℃ |
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Safety Information
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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Synonyms
| D:A-Friedooleanan-3-one |
| Einecs 209-205-1 |
| (4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-4,4a,6b,8a,11,11,12b,14a-Octamethylicosahydropicen-3(2H)-one |
| 3-oxofriedelane |
| (4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-4,4a,6b,8a,11,11,12b,14a-Octamethylicosahydro-3(2H)-picenone |
| 3-friedelanone |
| 3(2H)-Picenone, eicosahydro-4,4a,6b,8a,11,11,12b,14a-octamethyl-, (4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)- |
| Friedeline |
| FRIEDELAN-3-ONE |
| Friedelin |
| friedelane-3-one |
