CAS 59227-89-3|Laurocapram

Introduction:Basic information about CAS 59227-89-3|Laurocapram, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameLaurocapram
CAS Number59227-89-3Molecular Weight281.477
Density0.9±0.1 g/cm3Boiling Point404.9±14.0 °C at 760 mmHg
Molecular FormulaC18H35NOMelting Point-7ºC
MSDSUSAFlash Point165.2±10.7 °C

Names

NameLaurocapram
SynonymMore Synonyms

Laurocapram BiologicalActivity

DescriptionLaurocapram is a absorption enhancer and has been one of the most effective for substances of both lipophilic and hydrophilic nature[1].
Related CatalogResearch Areas >>OthersSignaling Pathways >>Others >>Others
References

[1]. López-Cervantes M, et al. Chemical enhancers for the absorption of substances through the skin: Laurocapram and its derivatives. Drug Dev Ind Pharm. 2006 Mar;32(3):267-86.

Chemical & Physical Properties

Density0.9±0.1 g/cm3
Boiling Point404.9±14.0 °C at 760 mmHg
Melting Point-7ºC
Molecular FormulaC18H35NO
Molecular Weight281.477
Flash Point165.2±10.7 °C
Exact Mass281.271851
PSA20.31000
LogP6.57
Vapour Pressure0.0±0.9 mmHg at 25°C
Index of Refraction1.466
InChIKeyAXTGDCSMTYGJND-UHFFFAOYSA-N
SMILESCCCCCCCCCCCCN1CCCCCC1=O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CM3995000
CHEMICAL NAME :
2H-Azepin-2-one, hexahydro-N-lauryl-
CAS REGISTRY NUMBER :
59227-89-3
BEILSTEIN REFERENCE NO. :
0167211
LAST UPDATED :
199806
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C18-H35-N-O
MOLECULAR WEIGHT :
281.54
WISWESSER LINE NOTATION :
T7NVTJ A12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960- Volume(issue)/page/year: 118,474,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

Safety Information

Hazard CodesXi
HS Code2933790090

Customs

HS Code2933790090
Summary2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Synonyms

1-dodecyl-hexahydro-azepin-2-one
MFCD00190580
2H-Azepin-2-one, 1-dodecylhexahydro-
tranzone
acecloguanosine
EINECS 261-668-9
1-Dodecylazepan-2-one
Lauocapram
1 dodecylperhydroazepin 2 one
AZONE
N-Dodecyl-e-caprolactam
azon
1-Dodecyl-2-azepanone
1-dodecylhexahydro-2H-azepin-2-one
usafnd-72
Laurocapram
1-N-dodecylazacycloheptan-2-one
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