CAS 557-04-0|Magnesium stearate

[1]. Zuurman K, et al. Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties[J]. International journal of pharmaceutics, 1999, 179(1): 107-115.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

CHEMICAL IDENTIFICATION

RTECS NUMBER :

WI4390000

CHEMICAL NAME :

Stearic acid, magnesium salt

CAS REGISTRY NUMBER :

557-04-0

LAST UPDATED :

199712

DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C36-H70-O4.Mg

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1092 gm/kg/13W-C

TOXIC EFFECTS :

Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 17,51,1980 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81884 No. of Facilities: 2092 (estimated) No. of Industries: 19 No. of Occupations: 34 No. of Employees: 31116 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6914 No. of Facilities: 64 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 320 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81884 No. of Facilities: 5057 (estimated) No. of Industries: 57 No. of Occupations: 78 No. of Employees: 184994 (estimated) No. of Female Employees: 101129 (estimated)

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