CAS 1185-57-5|Ferric ammonium citrate
| Common Name | Ferric ammonium citrate | ||
|---|---|---|---|
| CAS Number | 1185-57-5 | Molecular Weight | 261.975 |
| Density | 1.8 g/cm3 (20ºC) | Boiling Point | 197ºC |
| Molecular Formula | C6H8FeNO7 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Ammonium ferric citrate |
|---|---|
| Synonym | More Synonyms |
Ferric ammonium citrate BiologicalActivity
| Description | Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis[1]. Ammonium iron(III) citrate can enhance protein production[2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Apoptosis >>Ferroptosis |
| In Vitro | Ammonium iron(III) citrate (Ammonium ferric citrate; 1, 5, 10, 15 mM; 24 hours) with 5 mM induces cell death in HT1080 cells. AML12 cells were highly resistant to Ammonium iron(III) citrate, as they maintained cell viability about 80%. Ammonium iron(III) citrate can be actively transported into cells by specific transporter[1]. Ammonium iron(III) citrate (6, 12, 18 mg/L) has a higher biomas for Chlorella vulgaris FSP-E (CV) in BG-11 medium with 12 mg/L and 18 mg/L[2]. |
| References | [1]. Shenglin Fang, et al. Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [2]. Yu-Cheng Lai, et al. Towards protein production and application by using Chlorella species as circular economy. Bioresour Technol. 2019 Oct;289:121625. |
Chemical & Physical Properties
| Density | 1.8 g/cm3 (20ºC) |
|---|---|
| Boiling Point | 197ºC |
| Molecular Formula | C6H8FeNO7 |
| Molecular Weight | 261.975 |
| Exact Mass | 261.965027 |
| PSA | 102.37000 |
| InChIKey | AUALKMYBYGCYNY-UHFFFAOYSA-E |
| SMILES | O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Fe+3].[Fe+3].[Fe+3].[NH4+].[NH4+].[NH4+] |
| Water Solubility | 1200 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | UN 9118 |
| WGK Germany | 3 |
| RTECS | GE7540000 |
| HS Code | 2918150000 |
Customs
| HS Code | 2918150000 |
|---|---|
| Summary | 2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0% |
Articles30
More Articles| Iron overload causes oxidative stress and impaired insulin signaling in AML-12 hepatocytes. Dig. Dis. Sci. 58(7) , 1899-908, (2013) Iron overload is associated with increased severity of nonalcoholic fatty liver disease (NAFLD) including progression to nonalcoholic steatohepatitis and hepatocellular carcinoma.To identify potential... | |
| Effects of iron chelators, iron salts, and iron oxide nanoparticles on the proliferation and the iron content of oligodendroglial OLN-93 cells. Neurochem. Res. 35(8) , 1259-68, (2010) The oligodendroglial cell line OLN-93 was used as model system to investigate the consequences of iron deprivation or iron excess on cell proliferation. Presence of ferric or ferrous iron chelators in... | |
| Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter. Gut 95 , 1261-8, (2010) Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic i... |
Synonyms
| Ferric |
| EINECS 214-686-6 |
| Iron(3+) 2-hydroxy-1,2,3-propanetricarboxylate ammoniate (1:1:1) |
| Ferricammoniumcitrae |
| 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, ammonium iron(3+) salt (1:1:1) |
| MFCD00013099 |
| Ammonium iron(III) citrate |
| Ammonium Ferric Citrate |
| Ammoniumironcitrate |
| IRON AMMONIUM CITRATE |
| Citric acid iron ammonium |
| Amonium Iron(III) Citrate Supplement |
| Ironandammoniumcit-rate |
| AmmoniumFerricCitrateUsp |
