CAS 145-13-1|Pregnenolone
Introduction：Basic information about CAS 145-13-1|Pregnenolone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pregnenolone | ||
|---|---|---|---|
| CAS Number | 145-13-1 | Molecular Weight | 316.478 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 443.3±45.0 °C at 760 mmHg |
| Molecular Formula | C21H32O2 | Melting Point | 188-190 °C |
| MSDS | ChineseUSA | Flash Point | 188.9±21.3 °C |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | pregnenolone |
|---|---|
| Synonym | More Synonyms |
Pregnenolone BiologicalActivity
| Description | Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC). |
|---|---|
| Related Catalog | Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>Cannabinoid ReceptorResearch Areas >>Neurological DiseaseNatural Products >>Steroids |
| Target | CB1 Receptor Human Endogenous Metabolite |
| In Vitro | The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC)[1]. |
| In Vivo | Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1]. |
| Animal Admin | Mice and Rats[1] Adult male Wistar rats (weighing 320-340g), Sprague Dawley male rats (weighing 330-350g), C57BL/6N mice (2-3 months) and CD1 mice (weighing 25-30 g at the beginning of the experiments) are used. Pregnenolone is injected subcutaneously (sc). The injection volumes are 1 mL/kg of body weight for rats and 10 mL/kg for mice[1]. |
| References | [1]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 443.3±45.0 °C at 760 mmHg |
| Melting Point | 188-190 °C |
| Molecular Formula | C21H32O2 |
| Molecular Weight | 316.478 |
| Flash Point | 188.9±21.3 °C |
| Exact Mass | 316.240234 |
| PSA | 37.30000 |
| LogP | 4.52 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.550 |
| InChIKey | ORNBQBCIOKFOEO-UHFFFAOYSA-N |
| SMILES | CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
| Storage condition | 2~8℃ |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 35 mg/kg
- SEX/DURATION :
- female 7 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year: 102,347,1955
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H302 + H312 + H332-H319 |
| Precautionary Statements | P210-P280-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TU5560700 |
| HS Code | 2937290090 |
Customs
| HS Code | 2937290090 |
|---|
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Synonyms
| EINECS 205-647-4 |
| prenolon |
| ZK-5553 |
| MFCD00003628 |
| Pregn-5-en-20-one, 3-hydroxy- |
| prenenolone |
| Pregnelone |
| Pregnenlolone |
| 3-Hydroxypregn-5-en-20-one |
| Pregnenolone |
| 3β-Hydroxy-5-pregnen-20-one |
| 5-Pregnen-3β-ol-20-one |
| pregnolon |
| Progeserone |
