CAS 5949-29-1|Citric acid monohydrate
Introduction：Basic information about CAS 5949-29-1|Citric acid monohydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Citric acid monohydrate | ||
|---|---|---|---|
| CAS Number | 5949-29-1 | Molecular Weight | 210.139 |
| Density | 1.54 | Boiling Point | 56 °C760 mm Hg(lit.) |
| Molecular Formula | C6H10O8 | Melting Point | 135-152 ºC |
| MSDS | ChineseUSA | Flash Point | 173.9 ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Citric acid monohydrate |
|---|---|
| Synonym | More Synonyms |
Citric acid monohydrate BiologicalActivity
| Description | Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease |
| Target | Human Endogenous Metabolite |
| In Vitro | Citric acid monohydrate (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner[3]. Citric acid monohydrate (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3]. Citric acid monohydrate (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3]. Cell Viability Assay[3] Cell Line: HaCaT cells Concentration: 0, 2.5, 5, 7.5, 10, 12.5 mM Incubation Time: 24 h Result: Inhibited the cell viability in a dose dependent manner. Cell Cycle Analysis[3] Cell Line: HaCaT cells Concentration: 12.5 mM Incubation Time: 0, 12, 24, 48, 72 h Result: Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner. Western Blot Analysis[3] Cell Line: HaCaT cells Concentration: 12.5 mM Incubation Time: 12, 24, 48 h Result: Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl. |
| In Vivo | Citric acid monohydrate (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver[1]. Citric acid monohydrate (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes[1]. Citric acid monohydrate (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice[2]. Animal Model: 20 g male Kunming mice[2] Dosage: 120, 240, 480 mg/kg Administration: I.p.; weekly for 3 weeks Result: T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased. |
| References | [1]. Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. [2]. Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44. [3]. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20. |
Chemical & Physical Properties
| Density | 1.54 |
|---|---|
| Boiling Point | 56 °C760 mm Hg(lit.) |
| Melting Point | 135-152 ºC |
| Molecular Formula | C6H10O8 |
| Molecular Weight | 210.139 |
| Flash Point | 173.9 ºC |
| Exact Mass | 210.037567 |
| PSA | 141.36000 |
| Vapour density | 2 (vs air) |
| Vapour Pressure | 184 mm Hg ( 20 °C) |
| Index of Refraction | n20/D 1.359(lit.) |
| InChIKey | YASYEJJMZJALEJ-UHFFFAOYSA-N |
| SMILES | O.O=C(O)CC(O)(CC(=O)O)C(=O)O |
| Storage condition | Store at RT. |
| Stability | Stable. Incompatible with oxidizing agents, bases, reducing agents, nitrates. |
| Water Solubility | 1630 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Rinsed with water
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 23,281,1982 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 375 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A121-876 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3648 No. of Facilities: 715 (estimated) No. of Industries: 11 No. of Occupations: 15 No. of Employees: 17300 (estimated) No. of Female Employees: 9926 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38;R41 |
| Safety Phrases | S9-S16-S26-S37/39-S36/37/39 |
| RIDADR | UN 1090 3/PG 2 |
| WGK Germany | 1 |
| RTECS | AL3150000 |
| Packaging Group | I; II; III |
| HS Code | 2918140000 |
Customs
| HS Code | 2918199090 |
|---|---|
| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| EXTRAN AP 22 |
| monohydrate citric acid |
| ACETONE D |
| ACETONE 300 |
| Citric acid hydrate |
| citric acid monohydrate powder |
| 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) |
| citric acid hydride |
| MFCD00008765 |
| EINECS 200-662-2 |
| citric |
| 2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) |
| ACETONE 5000 |
| 2-Hydroxypropane-1,2,3-tricarboxylic acid hydrate (1:1) |
| ACETONUM |
| 2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate |
| METHYL KETONE |
| FEMA 3326 |
| Citric acid monohydrate |
| PROPANONE |
| Acide 2-hydroxy-1,2,3-propanetricarboxylique hydrate |
