CAS 110-94-1|Glutaric acid
Introduction：Basic information about CAS 110-94-1|Glutaric acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Glutaric acid | ||
|---|---|---|---|
| CAS Number | 110-94-1 | Molecular Weight | 132.115 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 302.9±15.0 °C at 760 mmHg |
| Molecular Formula | C5H8O4 | Melting Point | 95-98 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 151.2±16.9 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | glutaric acid |
|---|---|
| Synonym | More Synonyms |
Glutaric acid BiologicalActivity
| Description | Glutaric acid induces oxidative stress in brain of young rats. |
|---|---|
| Related Catalog | Natural Products >>Acids and AldehydesResearch Areas >>Metabolic Disease |
| Target | Human Endogenous Metabolite |
| In Vitro | Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM[1]. |
| References | [1]. de Oliveira Marques F, et al. acid induces oxidative stress in brain of young rats. Brain Res. 2003 Feb 21;964(1):153-8. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 302.9±15.0 °C at 760 mmHg |
| Melting Point | 95-98 °C(lit.) |
| Molecular Formula | C5H8O4 |
| Molecular Weight | 132.115 |
| Flash Point | 151.2±16.9 °C |
| Exact Mass | 132.042252 |
| PSA | 74.60000 |
| LogP | -1.04 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.477 |
| InChIKey | JFCQEDHGNNZCLN-UHFFFAOYSA-N |
| SMILES | O=C(O)CCCC(=O)O |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with bases, oxidizing agents, reducing agents. |
| Water Solubility | 430 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6 gm/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 34,1196,1940 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4684 No. of Facilities: 91 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1827 (estimated) No. of Female Employees: 432 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | MA3740000 |
| HS Code | 2932999099 |
Customs
| HS Code | 2917190090 |
|---|---|
| Summary | 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| Iressa |
| Pentanedioic acid |
| Irressat |
| 1,5-Pentanedioate |
| Propane-1,3-dicarboxylic acid |
| n-Pyrotartaric acid |
| 1,5-Pentanedioic acid |
| 1,3-propanedicarboxylic acid |
| EINECS 203-817-2 |
| hydrogen glutarate |
| Glutaric acid |
| ZD 1839 |
| Gefitinib |
| 1,3-Propanedicarboxylate |
| MFCD00004410 |
