CAS 156-57-0|Cysteamine Hydrochloride
Introduction：Basic information about CAS 156-57-0|Cysteamine Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cysteamine Hydrochloride | ||
|---|---|---|---|
| CAS Number | 156-57-0 | Molecular Weight | 113.610 |
| Density | 0.75 | Boiling Point | 116.4ºC at 760 mmHg |
| Molecular Formula | C2H8ClNS | Melting Point | 67-71 °C |
| MSDS | ChineseUSA | Flash Point | 24.2ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Cysteamine hydrochloride |
|---|---|
| Synonym | More Synonyms |
Cysteamine Hydrochloride BiologicalActivity
| Description | Cysteamine Hydrochloride is an agent for the treatment of nephropathic cystinosis and an antioxidant.Target: OthersCysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death [1]. Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes [2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Metabolic Disease |
| References | [1]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92. [2]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6. |
Chemical & Physical Properties
| Density | 0.75 |
|---|---|
| Boiling Point | 116.4ºC at 760 mmHg |
| Melting Point | 67-71 °C |
| Molecular Formula | C2H8ClNS |
| Molecular Weight | 113.610 |
| Flash Point | 24.2ºC |
| Exact Mass | 113.006599 |
| PSA | 64.82000 |
| LogP | 1.37720 |
| Vapour Pressure | 16.7mmHg at 25°C |
| InChIKey | OGMADIBCHLQMIP-UHFFFAOYSA-N |
| SMILES | Cl.NCCS |
| Storage condition | 2-8°C |
| Stability | Stable, but hygroscopic. Incompatible with strong oxidizing agents. |
| Water Solubility | VERY SOLUBLE |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1352 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 900 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 244 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 5 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 153,57,1985
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 5 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 153,57,1985
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S36/37/39-S26 |
| RIDADR | UN 3335 |
| WGK Germany | 3 |
| RTECS | KJ0200000 |
| HS Code | 2921199090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 2-AMino&CYSTEAMINE HCL |
| 1-Amino-2-mercaptoethane hydrochloride |
| 2-aminoethylmercaptan hydrochloride |
| 2-Mercapto ethyl amine hydrochloride |
| EINECS 205-858-1 |
| β-Mercapto ethylamine hydrochloride |
| CYSTEAMINE HCL SOLID |
| Cysteinamine Hydrochloride |
| thiol hydrochloride |
| 2-Mercaptoethylamine hydrochloride |
| Cysteamine Hydrochloride |
| 2-Aminoethanethiol hydrochloride (1:1) |
| Cysteamine (Hydrochloride) |
| 2-Aminoethanethiol Hydrochloride |
| Thioethanolamine hydrochloride |
| 2-Mercaptoethanamine Hydrochloride |
| CYSTEAMINIUM CHLORIDE |
| 2-Mercaptoethylamin |
| 2-amino-ethanethiol hydrochloride |
| 1-Aminoethane-2-thiol hydrochloride |
| Cysteamine HCl |
| mea hydrochloride |
| b-Mercaptoethylamine Hydrochloride |
| 2-Amino-ethanethiol.HCl |
| Ethanethiol, 2-amino-, hydrochloride (1:1) |
| β-Mercaptoethylamine hydrochloride |
| MFCD00012904 |
| Decarboxycysteine hydrochloride |
| 2-Amino-ethanethiol;hydrochloride |
| 2-Mercaptoethylammonium chloride |
| Aminoethanethiol hydrochloride |
