CAS 141626-36-0|Dronedarone

Introduction：Basic information about CAS 141626-36-0|Dronedarone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dronedarone BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Dronedarone
CAS Number	141626-36-0	Molecular Weight	556.756
Density	1.1±0.1 g/cm3	Boiling Point	683.9±65.0 °C at 760 mmHg
Molecular Formula	C₃₁H₄₄N₂O₅S	Melting Point	/
MSDS	/	Flash Point	367.4±34.3 °C

Names

Name	dronedarone
Synonym	More Synonyms

Dronedarone BiologicalActivity

Description	Dronedarone(Multaq) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF.IC50 value:Target: multichannel blocker
Related Catalog	Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>Neuronal Signaling >>mAChRResearch Areas >>Cardiovascular Disease
References	[1]. Piccinni C, et al.Trends in antiarrhythmic drug use after marketing authorization of dronedarone: comparison between Emilia Romagna (Italy) and Sweden.Eur J Clin Pharmacol. 2012 Sep 1. [2]. Benaim G, et al.The emerging role of amiodarone and dronedarone in Chagas disease.Nat Rev Cardiol. 2012 Aug 7. [3]. Rosman J, et al. Possible Proarrhythmia with Dronedarone.J Cardiovasc Electrophysiol. 2012 Jul 19. [4]. Kao DP, et al. Proarrhythmic Potential of Dronedarone: Emerging Evidence from Spontaneous Adverse Event Reporting.Pharmacotherapy. 2012 Jun 28. [5]. Manakshe G, Rao BH.Dronedarone-current status in management of atrial fibrillation.Indian Heart J. 2012 Mar-Apr;64(2):182-6. Epub 2012 Apr 28.

Description

Dronedarone(Multaq) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF.IC50 value:Target: multichannel blocker

Related Catalog

Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>Neuronal Signaling >>mAChRResearch Areas >>Cardiovascular Disease

References

[1]. Piccinni C, et al.Trends in antiarrhythmic drug use after marketing authorization of dronedarone: comparison between Emilia Romagna (Italy) and Sweden.Eur J Clin Pharmacol. 2012 Sep 1.

[2]. Benaim G, et al.The emerging role of amiodarone and dronedarone in Chagas disease.Nat Rev Cardiol. 2012 Aug 7.

[3]. Rosman J, et al. Possible Proarrhythmia with Dronedarone.J Cardiovasc Electrophysiol. 2012 Jul 19.

[4]. Kao DP, et al. Proarrhythmic Potential of Dronedarone: Emerging Evidence from Spontaneous Adverse Event Reporting.Pharmacotherapy. 2012 Jun 28.

[5]. Manakshe G, Rao BH.Dronedarone-current status in management of atrial fibrillation.Indian Heart J. 2012 Mar-Apr;64(2):182-6. Epub 2012 Apr 28.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	683.9±65.0 °C at 760 mmHg
Molecular Formula	C₃₁H₄₄N₂O₅S
Molecular Weight	556.756
Flash Point	367.4±34.3 °C
Exact Mass	556.297119
PSA	97.23000
LogP	7.58
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.564
InChIKey	ZQTNQVWKHCQYLQ-UHFFFAOYSA-N
SMILES	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1
Storage condition	-20°C

Safety Information

Hazard Codes	Xi
HS Code	3004909090

Customs

HS Code	3004909090

Synonyms

UNII-JQZ1L091Y2

N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide

Multaq

N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-1-benzofuran-5-yl)methanesulfonamide

Methanesulfonamide, N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-

Dronedarone

N-(2-Butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl)methanesulfonamide

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