CAS 1981-58-4|Sulfamethazine sodium salt
Introduction：Basic information about CAS 1981-58-4|Sulfamethazine sodium salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sulfamethazine sodium salt | ||
|---|---|---|---|
| CAS Number | 1981-58-4 | Molecular Weight | 300.312 |
| Density | 1.392g/cm3 | Boiling Point | 526.2ºC at 760mmHg |
| Molecular Formula | C12H13N4NaO2S | Melting Point | 176ºC |
| MSDS | ChineseUSA | Flash Point | 272.1ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide |
|---|---|
| Synonym | More Synonyms |
Sulfamethazine sodium salt BiologicalActivity
| Description | Sulfamethazine sodium (Sulfadimidine sodium) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine sodium in animal product is set at 100 µg/kg[1][2]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| Target | Bacterial[1] |
| In Vivo | Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1]. Animal Model: 19 healthy female pigs (6-week-old, 4.5-6.2 kg)[1] Dosage: 80 mg/kg Administration: Intravenous injection (Pharmacokinetic study) Result: The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01. |
| References | [1]. VAN Poucke LSG, et al. Pharmacokinetics and Tissue Residues of Sulfathiazole and Sulfamethazine in Pigs. J Food Prot. 1994 Sep;57(9):796-801. [2]. Sheng Y J, et al. Production of chicken yolk IgY to sulfamethazine: comparison with rabbit antiserum IgG. Food and Agricultural Immunology. 2015, 26(3):305-316. |
Chemical & Physical Properties
| Density | 1.392g/cm3 |
|---|---|
| Boiling Point | 526.2ºC at 760mmHg |
| Melting Point | 176ºC |
| Molecular Formula | C12H13N4NaO2S |
| Molecular Weight | 300.312 |
| Flash Point | 272.1ºC |
| Exact Mass | 300.065704 |
| PSA | 97.56000 |
| LogP | 2.99720 |
| Appearance of Characters | white to off-white |
| Vapour Pressure | 3.64E-11mmHg at 25°C |
| InChIKey | NGIVTUVVBWOTNT-UHFFFAOYSA-N |
| SMILES | Cc1cc(C)nc([N-]S(=O)(=O)c2ccc(N)cc2)n1.[Na+] |
| Storage condition | 2-8°C |
| Water Solubility | H2O: soluble50mg/mL |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1165 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 974 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 699 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 605 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4891 No. of Facilities: 299 (estimated) No. of Industries: 2 No. of Occupations: 18 No. of Employees: 3501 (estimated) No. of Female Employees: 883 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | WO9300000 |
| HS Code | 2935009090 |
Customs
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
Articles5
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| Depletion kinetics of 14C-sulfamethazine [4-amino-N-(4, 6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] metabolism in swine. Drug Metab. Dispos. 14 , 161, (1986) Swine weighing 60-70 kg were orally administered 14C-sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] at 12-hr intervals for 7 days (165 mg/dose; 0.126-5.04 mCi/mmol). ... |
Synonyms
| MFCD00068333 |
| Sodium sulfametazine |
| Sodium sulfamezathine |
| Bovibol |
| 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide |
| Sodium [(4-aminophenyl)sulfonyl](4,6-dimethylpyrimidin-2-yl)azanide |
| sulfamethazine sodium |
| 4-Amino-N-(4,6-dimethyl-2-pyrimidyl)benzenesulfonamide Sodium Salt |
| Sodium sulfamethiazine |
| sodium sulfamethazine |
| Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-, sodium salt (1:1) |
| Sulfadimidine sodium |
| Sodium [(4-aminophenyl)sulfonyl](4,6-dimethyl-2-pyrimidinyl)azanide |
| sodium sulfadimidinato |
| sulphadimidine sodium |
| Sodium sulfamethamide |
| sulfamethazine sodium salt |
| Sodium sulphamezathine |
