Introduction：Basic information about CAS 15722-48-2|5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoic acid), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoic acid) |
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| CAS Number | 15722-48-2 | Molecular Weight | 302.23900 |
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| Density | 1.55g/cm3 | Boiling Point | 653.233ºC at 760 mmHg |
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| Molecular Formula | C14H10N2O6 | Melting Point | / |
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| MSDS | / | Flash Point | 348.863ºC |
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Names
| Name | olsalazine |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity[1][2]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Leukotriene ReceptorResearch Areas >>Inflammation/Immunology |
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| Target | IC50: 0.39 mM (LTB4)[1] |
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| References | [1]. Nielsen, O.H., H.W. Verspaget, and J. Elmgreen, Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid. Aliment Pharmacol Ther, 1988. 2(3): p. 203-11. [2]. Horn H, et al. Modulation of arachidonic acid metabolism by olsalazine and other aminosalicylates in leukocytes. Scand J Gastroenterol. 1991 Aug;26(8):867-79. |
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Chemical & Physical Properties
| Density | 1.55g/cm3 |
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| Boiling Point | 653.233ºC at 760 mmHg |
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| Molecular Formula | C14H10N2O6 |
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| Molecular Weight | 302.23900 |
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| Flash Point | 348.863ºC |
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| Exact Mass | 302.05400 |
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| PSA | 139.78000 |
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| LogP | 2.90960 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.678 |
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| InChIKey | QQBDLJCYGRGAKP-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1cc(N=Nc2ccc(O)c(C(=O)O)c2)ccc1O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DG3482500
- CHEMICAL NAME :
- Benzoic acid, 3,3'-azobis(6-hydroxy-
- CAS REGISTRY NUMBER :
- 15722-48-2
- LAST UPDATED :
- 199807
- DATA ITEMS CITED :
- 1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 1714 mg/kg/34W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - interstitial nephritis
- REFERENCE :
- AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 100,238,1996
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2927000090 |
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Customs
| HS Code | 2927000090 |
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| Summary | 2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| Olsalazine |
| 5,5'-azosalicylic acid |
| Azodisal |
| Olsalazina |
| Olsalazinum [Latin] |
| 3,3'-Azobis(6-hydroxybenzoic acid) |
| 6,6'-Dihydroxy-3,3'-azo-di-benzoesaeure |
| 5,5'-Azobis(salicylic acid) |
| 6,6'-dihydroxy-3,3'-azo-di-benzoic acid |
| Eriochromflavin-A |
| C.I. Mordant Yellow 5 |
| Dipentum |
| Olsalazinum |
| MFCD00602469 |
| 5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-hydroxybenzoic acid |
| Rasal |
