CAS 144689-24-7|Olmesartan
| Common Name | Olmesartan | ||
|---|---|---|---|
| CAS Number | 144689-24-7 | Molecular Weight | 446.502 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 738.3±70.0 °C at 760 mmHg |
| Molecular Formula | C24H26N6O3 | Melting Point | 186-188ºC |
| MSDS | ChineseUSA | Flash Point | 400.3±35.7 °C |
Names
| Name | olmesartan |
|---|---|
| Synonym | More Synonyms |
Olmesartan BiologicalActivity
| Description | Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Angiotensin ReceptorResearch Areas >>Cardiovascular Disease |
| In Vivo | Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks[1]. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species[2]. |
| Animal Admin | Seven week-old male spontaneously hypertensive rats (SHR) are divided into five groups and fed a high fat diet (HFD) (60% kcal as fat) ad libitum. SHR are treated with vehicle (1% tragacanth gum solution), telmisartan (1 mg/kg), telmisartan (2 mg/kg), olmesartan (1 mg/kg) or olmesartan (2 mg/kg) once daily by gastric gavage. After more than 4 weeks-treatment, mean arterial blood pressure is measured for 24 h under a conscious state. |
| References | [1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7. [2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9. [3]. Komiya H, et al. Sleep/wakefulness behaviors in mice during pregnancy and pregnancy-associated hypertensive mice. Sleep. 2018 Mar 1;41(3). |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 738.3±70.0 °C at 760 mmHg |
| Melting Point | 186-188ºC |
| Molecular Formula | C24H26N6O3 |
| Molecular Weight | 446.502 |
| Flash Point | 400.3±35.7 °C |
| Exact Mass | 446.206635 |
| PSA | 129.81000 |
| LogP | 3.72 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.671 |
| InChIKey | VTRAEEWXHOVJFV-UHFFFAOYSA-N |
| SMILES | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 |
| Storage condition | -20°C Freezer |
Safety Information
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | NI4014100 |
| HS Code | 2921590090 |
Customs
| HS Code | 2921590090 |
|---|---|
| Summary | 2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles4
More Articles| Structure-response relationship in electrospray ionization-mass spectrometry of sartans by artificial neural networks. J. Chromatogr. A. 1438 , 123-32, (2016) Quantitative structure-property relationship (QSPR) methods are based on the hypothesis that changes in the molecular structure are reflected in changes in the observed property of the molecule. Artif... | |
| Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-κB inhibitor against HeLa human cell line. Toxicol. Mech. Methods 25 , 614-21, (2015) Over expression of renin-angiotensin system (RAS) and nuclear factor-kappaB (NF-κB) has a major role in many cancers. It has been suggested that some angiotensin receptor blockers (ARBs) could reduce ... | |
| Linear mixed-effects model of QTc prolongation for olmesartan medoxomil. J. Clin. Pharmacol. , doi:10.1002/jcph.572, (2015) |
Synonyms
| 4-(2-Hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid |
| Olmesartan Acid |
| MFCD00914967 |
| Olmesartan |
| 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid |
| 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- |
