Introduction：Basic information about CAS 80125-14-0|Remoxipride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Remoxipride |
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| CAS Number | 80125-14-0 | Molecular Weight | 371.26900 |
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| Density | 1.292 | Boiling Point | 439.9ºC at 760 mmHg |
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| Molecular Formula | C16H23BrN2O3 | Melting Point | / |
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| MSDS | / | Flash Point | 219.8ºC |
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Names
| Name | 3-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,6-dimethoxybenzamide |
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| Synonym | More Synonyms |
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Remoxipride BiologicalActivity
| Description | (S)-Remoxipride ((-)-Remoxipride) is a selective dopamine D2-receptor antagonist with an IC50 value of 1.57 μM. (S)-Remoxipride can be used for the research of psychotic disorder[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| Target | D2 Receptor:1.57 μM (IC50) D1 Receptor:＞100 μM (IC50) α1-Adrenoccptor:42 μM (IC50) |
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| In Vitro | (S)-Remoxipride (1-100 μM; 20 min) shows binding efficiency with IC50s of ＞100, 1.57 and 42 μM for dopamine D1, dopamine D2 and α1-Adrenoccptor, respectively[1]. |
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| In Vivo | (S)-Remoxipride (0.1-100 μM/kg; i.p. 60 min prior to apomorphine) blockades apomorphine-induced behaviors s in rats and vomiting in dogs[1]. (S)-Remoxipride (0.1-10 mg/kg; i.p. 30 min prior to apomorphine) displaces [3H]spiperone from both striatal and extra-striatal areas[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 0.1-100 μM/kg Administration: Intraperitoneal injection; 0.1-100 μM/kg; 60 min prior to apomorphine Result: Blocked apomorphine-induced hyperactivity and dose-dependent blockaded apomorphine-induced behaviors in vivo. Animal Model: Male and female beagle dogs[1] Dosage: 0.25-5 μM/kg Administration: Oral gavage; 0.25-5 μM/kg; 60 min prior to apomorphine Result: Blocked apomorphine-induced vomiting in dogs. |
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Chemical & Physical Properties
| Density | 1.292 |
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| Boiling Point | 439.9ºC at 760 mmHg |
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| Molecular Formula | C16H23BrN2O3 |
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| Molecular Weight | 371.26900 |
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| Flash Point | 219.8ºC |
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| Exact Mass | 370.08900 |
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| PSA | 50.80000 |
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| LogP | 3.00920 |
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| Index of Refraction | 1.54 |
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| InChIKey | GUJRSXAPGDDABA-NSHDSACASA-N |
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| SMILES | CCN1CCCC1CNC(=O)c1c(OC)ccc(Br)c1OC |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CV2368700
- CHEMICAL NAME :
- Benzamide, 3-bromo-2,6-dimethoxy-N-((1-ethyl-2-pyrrolidinyl)meth yl)-, (S)-
- CAS REGISTRY NUMBER :
- 80125-14-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C16-H23-Br-N2-O3
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 720 mg/kg/17W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Blood - hemorrhage Blood - aplastic anemia
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 342,1244,1993
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26-S36-S24/25 |
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| WGK Germany | 3 |
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Synonyms
| Remoxipridum [INN-Latin] |
| (S)-remoxipride |
| (S)-3-bromo-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,6-dimethoxybenzamide |
| Remoxiprida |
| (-)-N-ethyl-2-(3-bromo-2,6-dimethoxybenzamidomethyl)pyrrolidine |
| remoxipiride |
| S(-)-3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,6-dimethoxy-benzamide |
| remoxipride |
| FLA-731 |
| Romoxipride |
| Roxiam |
| Remoxipride [USAN:BAN:INN] |
| Remoxiprida [INN-Spanish] |
| Remoxipridum |
| MFCD00869705 |
