CAS 51598-60-8|Cimetropium bromide

Introduction：Basic information about CAS 51598-60-8|Cimetropium bromide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Cimetropium bromide BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Cimetropium bromide
CAS Number	51598-60-8	Molecular Weight	438.35500
Density	/	Boiling Point	/
Molecular Formula	C₂₁H₂₈BrNO₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Cimetropium bromide
Synonym	More Synonyms

Cimetropium bromide BiologicalActivity

Description	Cimetropium Bromide is a mAChR antagonist for long-term treatment of irritable bowel syndrome.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>Neuronal Signaling >>mAChRResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease
Target	mAChR[1]
In Vitro	Cimetropium Bromide behaves as a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations from both species, with affinity values (pA2) ranging between 7.41 and 7.82[1]. Cimetropium has potent antimuscarinic effect in inhibition of contraction of longitudinal muscle preparations. In the superfusion experiments of the preparation which has been preloaded with labelled choline, Cimetropium decreases the labelled ACh release induced by electrical field stimulation under the muscarinic autoinhibition blocked-condition[2].
In Vivo	When administered intravenously to conscious dogs provided with a colonic Thiry fistula, Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli. Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration with an ID50 of 27.9 μg/kg; both tonic and phasic components of contractile response are affected. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension[1].
References	[1]. Identification of orally administered cimetropium bromide in the colon of the rat and its possible local spasmolytic effect. [2]. Saitoh N, et al. Characterization of antimuscarinic effect of cimetropium bromide in guinea pig ileum. J Smooth Muscle Res. 1997 Feb;33(1):1-9.

Chemical & Physical Properties

Molecular Formula	C₂₁H₂₈BrNO₄
Molecular Weight	438.35500
Exact Mass	437.12000
PSA	59.06000
InChIKey	WDURTRGFUGAJHA-HNHWXVNLSA-M
SMILES	C[N+]1(CC2CC2)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12.[Br-]

Synonyms

Cimetropium

(7(S)-(1alpha,2beta,4beta,5alpha,7beta))-9-(Cyclopropylmethyl)-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo(3.3.1.0(sup 2,4))nonane bromide

N-Cyclopropvlmethylscopolamine bromide

Cimetropiumbromid

Cimetronin bromide

da3177

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