Introduction：Basic information about CAS 91300-60-6|LY83583, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LY83583 |
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| CAS Number | 91300-60-6 | Molecular Weight | 250.252 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 446.9±45.0 °C at 760 mmHg |
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| Molecular Formula | C15H10N2O2 | Melting Point | 184-185°C |
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| MSDS | USA | Flash Point | 224.1±28.7 °C |
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Names
| Name | 6-anilino-5,8-quinolinedione |
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| Synonym | More Synonyms |
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LY83583 BiologicalActivity
| Description | LY83583 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM[1]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Guanylate Cyclase |
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| References | [1]. Mülsch A, et al. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):119-25. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 446.9±45.0 °C at 760 mmHg |
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| Melting Point | 184-185°C |
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| Molecular Formula | C15H10N2O2 |
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| Molecular Weight | 250.252 |
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| Flash Point | 224.1±28.7 °C |
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| Exact Mass | 250.074234 |
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| PSA | 59.06000 |
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| LogP | 1.56 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.715 |
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| InChIKey | GXIJYWUWLNHKNW-UHFFFAOYSA-N |
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| SMILES | O=C1C(Nc2ccccc2)=CC(=O)c2ncccc21 |
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| Storage condition | 2-8°C |
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| Water Solubility | 0.1 M HCl: 1 mg/mL |
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Safety Information
| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R40 |
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| Safety Phrases | S36/37 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 2 |
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| HS Code | 2933499090 |
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Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 6-anilinoquinoline-5,8-dione |
| 6-(Phenylamino)quinoline-5,8-dione |
| 5,8-Quinolinedione, 6-(phenylamino)- |
| 6-ANILINO-5,8-QUINOLINEDIONE |
| MFCD00210756 |
