Introduction：Basic information about CAS 118409-58-8|(3,4,5-Trihydroxybenzylidene)malononitrile, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (3,4,5-Trihydroxybenzylidene)malononitrile |
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| CAS Number | 118409-58-8 | Molecular Weight | 202.17 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 500.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C10H6N2O3 | Melting Point | -220ºC dec. |
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| MSDS | / | Flash Point | 256.7±30.1 °C |
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Names
| Name | tyrphostin a25 |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase. Tyrphostin 25 is also a GPR35 agonist with an IC50 of 0.94 µM and an EC50 of 5.3 µM[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFRResearch Areas >>Inflammation/Immunology |
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| Target | EGFR tyrosine kinase[1] IC50: 0.94 µM (GPR35)[2] EC50: 5.3 µM (GPR35)[2] |
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| References | [1]. Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994 Nov;127(3):859-66. [2]. Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011 Jun 23;585(12):1957-62. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 500.8±50.0 °C at 760 mmHg |
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| Melting Point | -220ºC dec. |
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| Molecular Formula | C10H6N2O3 |
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| Molecular Weight | 202.17 |
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| Flash Point | 256.7±30.1 °C |
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| Exact Mass | 202.037842 |
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| PSA | 108.27000 |
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| LogP | 0.55 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.743 |
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| InChIKey | YZOFLYUAQDJWKV-UHFFFAOYSA-N |
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| SMILES | N#CC(C#N)=Cc1cc(O)c(O)c(O)c1 |
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| Storage condition | 2-8°C |
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| Stability | Light Sensitive |
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| Water Solubility | DMSO: >50 mg/mL, clear, yellow to orange |
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Safety Information
Synonyms
| (3,4,5-trihydroxybenzylidene)propanedinitrile |
| tyrphostin A-25 |
| Propanedinitrile, 2-[(3,4,5-trihydroxyphenyl)methylene]- |
| TYROPHOSTIN A25 |
| TYRPHOSTIN 25 |
| (3,4,5-Trihydroxybenzylidene)malononitrile |
