Introduction：Basic information about CAS 15639-50-6|Safingol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Safingol |
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| CAS Number | 15639-50-6 | Molecular Weight | 301.50800 |
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| Density | 0.927 g/cm3 | Boiling Point | 446.2ºC at 760 mmHg |
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| Molecular Formula | C18H39NO2 | Melting Point | 106.8 - 108.7 °C |
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| MSDS | ChineseUSA | Flash Point | 223.7ºC |
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Names
| Name | L-threo-Dihydrosphingosine |
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| Synonym | More Synonyms |
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Safingol BiologicalActivity
| Description | Safingol is a lyso-sphingolipid PKC (protein kinase C ) inhibitor[1]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>PKCResearch Areas >>CancerSignaling Pathways >>TGF-beta/Smad >>PKC |
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| References | [1]. Tsukamoto S, et al. Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs. Mol Cancer Ther. 2015 Oct;14(10):2303-12. |
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Chemical & Physical Properties
| Density | 0.927 g/cm3 |
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| Boiling Point | 446.2ºC at 760 mmHg |
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| Melting Point | 106.8 - 108.7 °C |
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| Molecular Formula | C18H39NO2 |
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| Molecular Weight | 301.50800 |
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| Flash Point | 223.7ºC |
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| Exact Mass | 301.29800 |
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| PSA | 66.48000 |
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| LogP | 4.84850 |
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| Vapour Pressure | 7.75E-10mmHg at 25°C |
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| Index of Refraction | 1.477 |
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| InChIKey | OTKJDMGTUTTYMP-ROUUACIJSA-N |
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| SMILES | CCCCCCCCCCCCCCCC(O)C(N)CO |
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| Storage condition | 20°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2922199090 |
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Customs
| HS Code | 2922199090 |
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| Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles29
More Articles
| Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site. Biochem. J. 461(2) , 213-22, (2014) Lipid-conjugated peptides have advanced the understanding of membrane protein functions and the roles of lipids in the membrane milieu. These lipopeptides modulate various biological systems such as v... | |
| Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. Arch. Biochem. Biophys. 526(1) , 60-8, (2012) The role of sphingolipids in clathrin-mediated endocytosis is only poorly understood in mammalian cells. Thus the relationship between sphingolipid de novo synthesis and clathrin-mediated endocytosis ... | |
| Terpene alcohols inhibit de novo sphingolipid biosynthesis. Planta Med. 78(5) , 434-9, (2012) The terpene alcohols geranyllinalool, phytol (diterpene alcohol), and farnesol (sesquiterpene alcohol) were newly found to inhibit sphingolipid de novo biosynthesis in LLC-PK₁ cells (pig kidney epithe... | |
Synonyms
| MFCD00792847 |
| L-threo sphinganine,2S,3S) L-threo-2-amino-1,3-octadecanediol |
| L-THREO-DIHYDROSPHINGOSINE |
