Introduction：Basic information about CAS 843666-40-0|Boc-C16-COOH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Boc-C16-COOH |
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| CAS Number | 843666-40-0 | Molecular Weight | 370.56600 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C22H42O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid |
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| Synonym | More Synonyms |
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Boc-C16-COOH BiologicalActivity
| Description | Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Molecular Formula | C22H42O4 |
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| Molecular Weight | 370.56600 |
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| Exact Mass | 370.30800 |
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| PSA | 63.60000 |
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| LogP | 6.65430 |
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| InChIKey | WDUQJXKBWRNMKI-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCC(=O)O |
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Safety Information
| Hazard Codes | Xn |
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| HS Code | 2918990090 |
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Customs
| HS Code | 2918990090 |
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| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Octadecanedioicacid,mono(1,1-dimethylethyl) ester (9CI) |
| Octadecanedioic acid,1-(1,1-dimethylethyl) ester |
| Octadecanedioic acid mono-tert-butyl ester |
| 18-tert-butoxy-18-oxooctadecanoic acid |
