Introduction：Basic information about CAS 405090-31-5|Ethyl 3-azetidinecarboxylate hydrochloride (1:1), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ethyl 3-azetidinecarboxylate hydrochloride (1:1) |
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| CAS Number | 405090-31-5 | Molecular Weight | 165.618 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C6H12ClNO2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Ethyl azetidine-3-carboxylate hydrochloride |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Molecular Formula | C6H12ClNO2 |
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| Molecular Weight | 165.618 |
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| Exact Mass | 165.055649 |
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| PSA | 38.33000 |
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| LogP | 0.89970 |
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| InChIKey | RZQFZRLGHCCPGG-UHFFFAOYSA-N |
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| SMILES | CCOC(=O)C1CNC1.Cl |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Ethyl 3-azetidinecarboxylate hydrochloride (1:1) |
| ethyl azetidine-3-carboxylate,hydrochloride |
| 3-Azetidinecarboxylic acid, ethyl ester, hydrochloride (1:1) |
