CAS 57159-62-3|N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE

Introduction：Basic information about CAS 57159-62-3|N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE
CAS Number	57159-62-3	Molecular Weight	307.09800
Density	1.69 g/cm3	Boiling Point	/
Molecular Formula	C₉H₁₁BrN₂O₅	Melting Point	93-94ºC
MSDS	/	Flash Point	/

Names

Name	N-Succinimidyl 3-(Bromoacetamido)propionate
Synonym	More Synonyms

BiologicalActivity

Description	N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	PEGs Alkyl/ether Cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

Density	1.69 g/cm3
Melting Point	93-94ºC
Molecular Formula	C₉H₁₁BrN₂O₅
Molecular Weight	307.09800
Exact Mass	305.98500
PSA	92.78000
Index of Refraction	1.566
InChIKey	WGMMKWFUXPMTRW-UHFFFAOYSA-N
SMILES	O=C(CBr)NCCC(=O)ON1C(=O)CCC1=O

Safety Information

Hazard Codes	Xi
HS Code	2925190090

Customs

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Synonyms

(2,5-dioxopyrrolidin-1-yl) 3-[(2-bromoacetyl)amino]propanoate

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