CAS 756525-91-4|Boc-NH-PEG4-CH2CH2COOH

Introduction：Basic information about CAS 756525-91-4|Boc-NH-PEG4-CH2CH2COOH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameBoc-NH-PEG4-CH2CH2COOH
CAS Number756525-91-4Molecular Weight365.419
Density1.1±0.1 g/cm3Boiling Point504.5±50.0 °C at 760 mmHg
Molecular FormulaC16H31NO8Melting Point/
MSDSChineseUSAFlash Point258.9±30.1 °C

Names

Name3-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
SynonymMore Synonyms

Boc-NH-PEG4-CH2CH2COOH BiologicalActivity

DescriptionBoc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[2].
Related CatalogResearch Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

PEGs

Alkyl/ether

In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
References

[1]. Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2018114798A1.

[2]. Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1.

Chemical & Physical Properties

Density1.1±0.1 g/cm3
Boiling Point504.5±50.0 °C at 760 mmHg
Molecular FormulaC16H31NO8
Molecular Weight365.419
Flash Point258.9±30.1 °C
Exact Mass365.204956
PSA112.55000
LogP-0.14
Vapour Pressure0.0±2.8 mmHg at 25°C
Index of Refraction1.466
InChIKeyYEIYIPDFZMLJQH-UHFFFAOYSA-N
SMILESCC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)O

Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADRNONH for all modes of transport

Synonyms

15-T-BUTYLOXYCARBONYLAMINO-4,7,10,13-TETRAOXA-PENTADECANOIC ACID
2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic acid
3,8,11,14,17-Pentaoxa-5-azaeicosan-20-oic acid, 2,2-dimethyl-4-oxo-
AmbotzPEG1920
CAS 872857-53-9|N-(5-chloro-2-methylphenyl)-2-(1-(2-morpholino-2-oxoethyl)-1H-indol-3-yl)-2-oxoaceta
CAS 204320-65-0|1-(METHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID
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