Introduction：Basic information about CAS 20525-20-6|4′-Bromoflavone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4′-Bromoflavone |
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| CAS Number | 20525-20-6 | Molecular Weight | 301.13 |
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| Density | 1.54g/cm3 | Boiling Point | 406.6ºC at 760 mmHg |
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| Molecular Formula | C15H9BrO2 | Melting Point | 174-176ºC |
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| MSDS | / | Flash Point | 199.7ºC |
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Names
| Name | 2-(4-bromophenyl)chromen-4-one |
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| Synonym | More Synonyms |
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4′-Bromoflavone BiologicalActivity
| Description | 4′-Bromoflavone, a cancer chemopreventive agent, is a potent phase II detoxification enzymes inducer[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | 4′-Bromoflavone significantly induces quinone reductase (QR) activity in cultured murine hepatoma 1c1c7 cells (concentration to double activity: 10 nM) and effectively induces the α- and mu-isoforms of glutathione S-transferase in cultured H4IIE rat hepatoma cells with no observed toxicity[1]. 4′-Bromoflavone is a potent inhibitor of cytochrome P4501A1-mediated ethoxyresorufin-O-deethylase activity, with an IC50 of 0.86 μM. In HepG2 or MCF-7 cells, 4′-Bromoflavone significantly reduces the covalent binding of metabolically activated benzo[a]pyrene to cellular DNA[1]. |
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| In Vivo | In short-term dietary studies, 4′-Bromoflavone is also shown to increase QR activity and glutathione levels in rat liver, mammary gland, colon, stomach, and lung in a dose-dependent manner. In studies conducted with female Sprague Dawley rats ,4′-Bromoflavone significantly increases QR activity (phase II enzyme)[1]. In DMBA-treated female Sprague Dawley rats. Dietary administration of 4′-Bromoflavone (2000 and 4000 mg/kg of diet, from 1 week before to 1 week after DMBA) significantly inhibits the incidence and multiplicity of mammary tumors and greatly increases tumor latency[1]. |
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| References | [1]. L L Song, et al. Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes. Cancer Res. 1999 Feb 1;59(3):578-85. |
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Chemical & Physical Properties
| Density | 1.54g/cm3 |
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| Boiling Point | 406.6ºC at 760 mmHg |
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| Melting Point | 174-176ºC |
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| Molecular Formula | C15H9BrO2 |
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| Molecular Weight | 301.13 |
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| Flash Point | 199.7ºC |
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| Exact Mass | 299.97900 |
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| PSA | 30.21000 |
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| LogP | 4.22250 |
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| Vapour Pressure | 8.07E-07mmHg at 25°C |
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| Index of Refraction | 1.656 |
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| InChIKey | URZUAHXELZUWFE-UHFFFAOYSA-N |
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| SMILES | O=c1cc(-c2ccc(Br)cc2)oc2ccccc12 |
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Safety Information
Customs
| HS Code | 2914700090 |
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| Summary | HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 4'-Bromo-flavone |
| 4'-bromofalvone |
