CAS 20362-54-3|2-(1,3-thiazol-2-yldisulfanyl)-1,3-thiazole

Introduction：Basic information about CAS 20362-54-3|2-(1,3-thiazol-2-yldisulfanyl)-1,3-thiazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name2-(1,3-thiazol-2-yldisulfanyl)-1,3-thiazole
CAS Number20362-54-3Molecular Weight232.36900
Density/Boiling Point/
Molecular FormulaC6H4N2S4Melting Point/
MSDS/Flash Point/

Names

Name2-(1,3-thiazol-2-yldisulfanyl)-1,3-thiazole
SynonymMore Synonyms

BiologicalActivity

DescriptionFBPase-IN-1 is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with an IC50 of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway of FBPase and affects the catalytic activity of FBPase[1].
Related CatalogSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
Target

IC50: 0.22 μM (FBPase)[1]

In VitroFBPase-IN-1 (compund 3a) (1.5625-200 μM, 48 hours) shows a low cytotoxicity with an IC50 of 75.08 μM[1]. FBPase-IN-1 (0-45 min) inhibits FBPase in a time-dependent manner, with IC50 decreasing from 0.28 to 0.09 μM, shows FBPase-IN-1 is an irreversible covalent inhibitor of FBPase[1].
In VivoFBPase-IN-1 (12 h-fasted ICR mouse, n = 6, male, 25 mg/kg, IP) shows good FBPase inhibitory activity (IC50 = 0.22 μM), satisfying glucose-lowering effect in vivo (54% reduction in blood glucose at 25 mg/kg)[1]. FBPase-IN-1 (6 or 7 weeks, ICR mice, n = 6, male, 25 mg/kg, IP for 4 hours, once) reduces blood glucose levels by targeting FBPase and inhibiting the GNG process[1]. Animal Model: ICR mouse (12 h-fasted, n = 6, male)[1] Dosage: 25 mg/kg Administration: IP, once Result: Lowered glucose. Animal Model: ICR mice (6 or 7 weeks, n = 6, male)[1] Dosage: 25 mg/kg Administration: IP, for 4 h, once Result: Reduced blood glucose levels by targeting FBPase and inhibiting the GNG process.
References

[1]. Xu YX, Huang YY, Song RR, et al. Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes. Eur J Med Chem. 2020; 203: 112500.

Chemical & Physical Properties

Molecular FormulaC6H4N2S4
Molecular Weight232.36900
Exact Mass231.92600
PSA132.86000
LogP3.39900
InChIKeyMZIWZDMEFARRSI-UHFFFAOYSA-N
SMILESc1csc(SSc2nccs2)n1

Safety Information

HS Code2934100090

Customs

HS Code2934100090
Summary2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Synonyms

Thiazole,2,2'-dithiobis
2-thiazol-2-yldisulfanyl-thiazole
THI022
Bis-thiazol-2-yl-disulfid
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