CAS 42438-89-1|Pinostilbene

Introduction：Basic information about CAS 42438-89-1|Pinostilbene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Pinostilbene BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Pinostilbene
CAS Number	42438-89-1	Molecular Weight	242.270
Density	1.3±0.1 g/cm3	Boiling Point	454.3±33.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₄O₃	Melting Point	117-118℃
MSDS	ChineseUSA	Flash Point	228.5±25.4 °C

Names

Name	3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxyphenol
Synonym	More Synonyms

Pinostilbene BiologicalActivity

Description	Pinostilbene is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
In Vitro	Pinostilbene (0- 40 μM; 24 hours, 48 hours) does not cause significant inhibition on the growth of normal colon cells[1]. Pinostilbene (20 μM, 40 μM; 24 hours, 48 hours) causes a significant and dose-dependent increase in the percentage of cells in S phase in both HCT116 and HT29 cells compared to the control cells[1]. Pinostilbene at μM also induces a modest increase of cell population in G2/M phase in HT29 cells[1]. Pinostilbene(20 μM, 40 μM; 24 hours, 48 hours) modulates expression of key signaling proteins related to cell proliferation and apoptosis[1]. Pinostilbene also acts as a resveratrol methylated derivative and displays protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells[2]. Cell Viability Assay[1] Cell Line: HCT116 cells, HT29 cells Concentration: 24 hours, 48 hours Incubation Time: 0-100 μM Result: Inhibited the growth of two human colon cancer cells. Apoptosis Analysis[1] Cell Line: HCT116 cells, HT29 cells Concentration: 20 μM, 40 μM Incubation Time: 24 hours, 48 hours Result: Caused a significant and dose-dependent increase in the percentage of cells in S phase. Cell Viability Assay[1] Cell Line: HCT116 cells Concentration: 20 μM,40 μM Incubation Time: 24 hours, 48 hours Result: Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21Cip1/Waf1, while decreased the expression levels of cyclin E and p-Rb.
References	[1]. Sun Y, et al. Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells. Mol Nutr Food Res. 2016 Sep;60(9):1924-32. [2]. Chao J, et al. Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. J Nutr Biochem. 2010 Jun;21(6):482-9.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	454.3±33.0 °C at 760 mmHg
Melting Point	117-118℃
Molecular Formula	C₁₅H₁₄O₃
Molecular Weight	242.270
Flash Point	228.5±25.4 °C
Exact Mass	242.094299
PSA	49.69000
LogP	3.80
Appearance of Characters	white to tan
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.692
Storage condition	2-8°C
Water Solubility	DMSO: ≥13mg/mL

Safety Information

Hazard Codes	Xi,N
Risk Phrases	37/38-41-50
Safety Phrases	26-39-61
RIDADR	UN 3077 9 / PGIII
HS Code	2909500000

Customs

HS Code	2909500000
Summary	2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Synonyms

mono-methylated resveratrol

3,4'-Dihydroxy-5-methoxy-trans-stilbene

3-[(E)-2-(4-Hydroxyphenyl)vinyl]-5-methoxyphenol

Pinostilbene

Pinostilbene hydrate

3-methoxyresveratrol

trans-3,4'-dihydroxy-5-methoxystilbene

phenol (3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy

5,4'-dihydroxy-3-methoxystilbene

trans-Pinostilbene

3-methoxy-4',5-dihydroxy-trans-stilbene

4,3'-dihydroxy-5'-methoxystilbene

Phenol, 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-

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