Introduction：Basic information about CAS 548-57-2|Lucanthone hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lucanthone hydrochloride |
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| CAS Number | 548-57-2 | Molecular Weight | 376.94 |
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| Density | / | Boiling Point | 512.4ºC at 760 mmHg |
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| Molecular Formula | C20H25ClN2OS | Melting Point | 195-196ºC |
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| MSDS | / | Flash Point | 263.7ºC |
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Names
| Name | lucanthone hydrochloride |
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| Synonym | More Synonyms |
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Lucanthone hydrochloride BiologicalActivity
| Description | Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1). |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Autophagy >>Autophagy |
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| Target | APE-1[1] |
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| In Vitro | Lucanthone hydrochloride is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone hydrochloride, cell viability is measured by MTT assay. Lucanthone hydrochloride reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone hydrochloride is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results[2]. |
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| References | [1]. Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18. [2]. Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13. |
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Chemical & Physical Properties
| Boiling Point | 512.4ºC at 760 mmHg |
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| Melting Point | 195-196ºC |
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| Molecular Formula | C20H25ClN2OS |
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| Molecular Weight | 376.94 |
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| Flash Point | 263.7ºC |
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| Exact Mass | 376.13800 |
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| PSA | 60.58000 |
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| LogP | 5.35180 |
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| InChIKey | LAOOXBLMIJHMFO-UHFFFAOYSA-N |
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| SMILES | CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12.Cl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- XO1605800
- CHEMICAL NAME :
- Thioxanthen-9-one, 1-(2-(diethylaminoethyl)amino)-4-methyl-, monohydrochloride
- CAS REGISTRY NUMBER :
- 548-57-2
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C20-H24-N2-O-S.Cl-H
- MOLECULAR WEIGHT :
- 376.98
- WISWESSER LINE NOTATION :
- T C666 BS IVJ D1 GM2N2&2 &GH
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 181 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 1 mg/L/2H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 59,61,1979
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Safety Information
Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-(2-Diaethylamino-aethylamino)-4-methyl-thioxanthen-9-on,Hydrochlorid |
| 1-(2-Diethylamino-ethylamino)-4-methylthiaxanthon,Lucanthon |
| Lycanthone |
| 1-(2-diethylamino-ethylamino)-4-methyl-thioxanthen-9-one,hydrochloride |
| thioxanthone |
| 1-(2-diethylamino-ethylamino)-4-methyl-thioxanthen-9-one |
| 1-<2-Diaethylamino-aethylamino>-4-methyl-thioxanthenon-(9) |
| 1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one |
| 1-(2-Diaethylamino-aethylamino)-4-methyl-thioxanthen-9-on |
