CAS 304-84-7|Etamivan

Introduction：Basic information about CAS 304-84-7|Etamivan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Etamivan BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles11
8. Synonyms

Common Name	Etamivan
CAS Number	304-84-7	Molecular Weight	223.26800
Density	1.115g/cm3	Boiling Point	401.4ºC at 760mmHg
Molecular Formula	C₁₂H₁₇NO₃	Melting Point	96-97ºC
MSDS	ChineseUSA	Flash Point	196.6ºC
Symbol	GHS06	Signal Word	Danger

Names

Name	N,N-diethyl-4-hydroxy-3-methoxybenzamide
Synonym	More Synonyms

Etamivan BiologicalActivity

Description	Etamivan is a respiratory stimulant drug, mainly used in the treatment of barbiturate overdose and chronic obstructive pulmonary disease.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

Chemical & Physical Properties

Density	1.115g/cm3
Boiling Point	401.4ºC at 760mmHg
Melting Point	96-97ºC
Molecular Formula	C₁₂H₁₇NO₃
Molecular Weight	223.26800
Flash Point	196.6ºC
Exact Mass	223.12100
PSA	49.77000
LogP	1.88280
Index of Refraction	1.536
InChIKey	BQJODPIMMWWMFC-UHFFFAOYSA-N
SMILES	CCN(CC)C(=O)c1ccc(O)c(OC)c1
Storage condition	2-8℃
Water Solubility	methanol: 0.1 g/mL, clear

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YW5250000

CHEMICAL NAME :: Vanillamide, N,N-diethyl-

CAS REGISTRY NUMBER :: 304-84-7

BEILSTEIN REFERENCE NO. :: 2694478

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H17-N-O3

MOLECULAR WEIGHT :: 223.30

WISWESSER LINE NOTATION :: 2N2&VR DQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 154 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 17,41,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 243,609,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 9,67,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 67 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - rigidity (including catalepsy)

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 1,423,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - rigidity (including catalepsy)

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 1,423,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 57 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - rigidity (including catalepsy)

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 1,423,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,377,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,377,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,377,1972

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	25
Safety Phrases	36/37/39-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	YW5250000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2924299090

Customs

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles11

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Pentylenetetrazol and ethamivan effects on brain serotonin metabolism.

Life Sci. 9 , 831, (1970)

Antihypoxidotic and nootropic drugs: proof of their encephalotropic and pharmacodynamic properties by quantitative EEG investigations.

Prog. Neuropsychopharmacol. 4(4-5) , 469-89, (1980)

Synonyms

N,N-Diethylvanillamide

ETHAMIVAN

Diethamivan

Simaron

N,N-DIETHYLVANILLAMIDE

N,N-diethyl-3-methoxy-4-hydroxybenzamide

4-hydroxy-3-methoxydiethylbenzamide

Corivanil

Vanillic acid diethylamide

vanillic acid N,N-diethyl amide

Ethamivan N,N-Diethyl-4-hydroxy-3-methoxybenzamide N,N-Diethylvanillamide

Etamivan

N,N-diethyl-4-hydroxy-3-methoxy-benzamide

Cardiovanil

Cardiovamil

Analepticon

Recommended......