CAS 122752-15-2|Deltorphin I TFA

Introduction：Basic information about CAS 122752-15-2|Deltorphin I TFA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameDeltorphin I TFA
CAS Number122752-15-2Molecular Weight768.85600
Density1.284g/cm3Boiling Point1242.4ºC at 760mmHg
Molecular FormulaC37H52N8O10Melting Point/
MSDS/Flash Point705.2ºC

Names

Name(3S)-3-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
SynonymMore Synonyms

Deltorphin I TFA BiologicalActivity

DescriptionDeltorphin I is a δ-opioid receptor agonist with high affinity and selectivity.
Related CatalogSignaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological DiseasePeptides
Target

δ-opioid receptor[1]

In VivoTwice daily administration of Deltorphin I (20μg/mouse) for 4 days produces tolerance to Deltorphin I analgesia, as shown by the decrease in the analgesic response. The peak analgesic response to Deltorphin I (20 μg/mouse) at 10 min after injections is decreased from 8.36±0.28 s (the 1st day) to 4.53±0.14 s (the 4th day) markedly. Concurrent treatment of Melatonin (0.5, 1 and 2.5 mg/kg) and Deltorphin I (20 μg/mouse) twice daily for 4 days can attenuate the tolerance to Deltorphin I analgesia (P<0.05, <0.05 and <0.05), and this effect is dose dependent[1].
Animal AdminMice[1] Male Kunming mice (20.0±1.0 g) are used. In order to investigate the chronic effect of Melatonin on opioid receptor agonist analgesia, 18, 17, 16 and 21 mice are treated with Melatonin (0, 0.5, 1 and 2.5 mg/kg, respectively) twice daily for 4 days. On the 5th day, 8, 8, 8 and 9 mice are administered with Endomorphin-1 18 μg/mouse (corresponding to 0, 0.5, 1 and 2.5 mg/kg Melatonin, respectively), while 10, 9, 8 and 12 mice are administered with Deltorphin I 20 μg/mouse (corresponding to 0, 0.5, 1 and 2.5 mg/kg Melatonin, respectively). Subsequently tail-flick latency is measured at 10 min interval within 60 min[1].
References

[1]. Dai X, et al. Melatonin attenuates the development of antinociceptive tolerance to delta-, but not to mu-opioid receptor agonist in mice. Behav Brain Res. 2007 Aug 22;182(1):21-7.

Chemical & Physical Properties

Density1.284g/cm3
Boiling Point1242.4ºC at 760mmHg
Molecular FormulaC37H52N8O10
Molecular Weight768.85600
Flash Point705.2ºC
Exact Mass768.38100
PSA301.24000
LogP2.08280
Vapour Pressure0mmHg at 25°C
Index of Refraction1.578
InChIKeyCJAORFIPPWIGPG-QXYJMILXSA-N
SMILESCC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc1ccccc1)C(=O)NC(CC(=O)O)C(=O)NC(C(=O)NC(C(=O)NCC(N)=O)C(C)C)C(C)C
Storage condition2-8℃

Synonyms

H-Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2
deltorphin I
Deltorphin C
Tyr-D-Ala-Phe-Asp-Val-Val-Cly-NH2
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