Introduction：Basic information about CAS 75520-41-1|Acetyl coenzyme A trilithium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Acetyl coenzyme A trilithium |
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| CAS Number | 75520-41-1 | Molecular Weight | 827.370 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C23H35Li3N7O17P3S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Acetyl coenzyme A trilithium salt |
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| Synonym | More Synonyms |
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Acetyl coenzyme A trilithium BiologicalActivity
| Description | Acetyl-coenzyme A (Acetyl-CoA) trilithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trilithium regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trilithium is also a key precursor of lipid synthesis[1][2][3][4]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Metabolic Disease |
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| In Vitro | Acetyl coenzyme A trilithium increases cytoplasmic protein acetylation in starved U2OS cells while reducing starvation-induced autophagic fluxes. (U2OS cells stably expressing GFP-LC3 and are microinjected with Acetyl coenzyme A; incubated in nutrient-free conditions in the presence of 100 nM BafA1 and fixed after 3 h)[2]. |
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| In Vivo | Acetyl coenzyme A trilithium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy[2][3].Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A concentrations in the brain and actually increase hepatic Acetyl coenzyme A and protein acetylation levels[4]. |
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| References | [1]. Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50. [2]. Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25. [3]. Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93. [4]. Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21. |
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Chemical & Physical Properties
| Molecular Formula | C23H35Li3N7O17P3S |
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| Molecular Weight | 827.370 |
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| Exact Mass | 827.150330 |
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| PSA | 421.19000 |
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| LogP | 0.48580 |
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| InChIKey | MOGXDJCKYPGZRO-JHJDYNLLSA-N |
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| SMILES | CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(n2cnc3c(N)ncnc32)C(O)C1OP(=O)(O)O.[Li].[Li].[Li] |
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Safety Information
| Hazard Codes | Xi:Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36/37 |
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Synonyms
| Adenosine, 5'-O-[[[[(3R)-4-[[3-[[2-(acetylthio)ethyl]amino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]hydroxyphosphinyl]oxy]hydroxyphosphinyl]-, 3'-(dihydrogen phosphate), lithium salt (1:3) |
| acetyl coenzyme a trilithium salt |
