Introduction：Basic information about CAS 3541-42-2|(2E)-3-(2-hydroxyphenyl)prop-2-enal, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (2E)-3-(2-hydroxyphenyl)prop-2-enal |
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| CAS Number | 3541-42-2 | Molecular Weight | 148.16 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 311.3±17.0 °C at 760 mmHg |
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| Molecular Formula | C9H8O2 | Melting Point | 126ºC |
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| MSDS | USA | Flash Point | 131.8±13.5 °C |
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Names
| Name | 2-hydroxycinnamaldehyde |
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| Synonym | More Synonyms |
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(2E)-3-(2-hydroxyphenyl)prop-2-enal BiologicalActivity
| Description | 2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>STATSignaling Pathways >>Apoptosis >>ApoptosisSignaling Pathways >>Stem Cell/Wnt >>WntSignaling Pathways >>JAK/STAT Signaling >>STATResearch Areas >>Inflammation/Immunology |
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| References | [1]. Lee MA, et al. Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling. J Nat Prod. 2013 Jul 26;76(7):1278-84. [2]. Yoon YJ, et al. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2. Cancer Lett. 2018 Oct 10;434:42-55. [3]. Hao Let al. 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp Mol Med. 2021 May;53(5):875-884. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 311.3±17.0 °C at 760 mmHg |
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| Melting Point | 126ºC |
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| Molecular Formula | C9H8O2 |
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| Molecular Weight | 148.16 |
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| Flash Point | 131.8±13.5 °C |
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| Exact Mass | 148.052429 |
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| PSA | 37.30000 |
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| LogP | 2.14 |
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| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
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| Index of Refraction | 1.618 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- GD6565000
- CHEMICAL NAME :
- Cinnamaldehyde, o-hydroxy-
- CAS REGISTRY NUMBER :
- 3541-42-2
- LAST UPDATED :
- 199209
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C9-H8-O2
- MOLECULAR WEIGHT :
- 148.17
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 19,191,1985
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Safety Information
| Hazard Codes | Xn |
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| HS Code | 2912499000 |
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Customs
| HS Code | 2912499000 |
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| Summary | 2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
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Synonyms
| (2E)-3-(2-Hydroxyphenyl)acrylaldehyde |
| Hydroxycinnamaldehyde |
| o-hydroxycinnamaldehyde |
| (2E)-3-(2-hydroxyphenyl)prop-2-enal |
| 2'-hydroxycinnamaldehyde |
| 3-(2-Hydroxyphenyl)acrylaldehyde |
| 2-Propenal, 3-(2-hydroxyphenyl)-, (2E)- |
| 2-Hydroxy-zimtaldehyd |
| 2-hydroxycinnamicaldehyde |
| o-hydroxy-cinnamaldehyd |
