Introduction：Basic information about CAS 26098-04-4|gentamycin C1a, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | gentamycin C1a |
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| CAS Number | 26098-04-4 | Molecular Weight | 449.54200 |
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| Density | 1.36g/cm3 | Boiling Point | 675.2ºC at 760 mmHg |
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| Molecular Formula | C19H39N5O7 | Melting Point | 102-108ºC |
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| MSDS | / | Flash Point | 362.1ºC |
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Names
| Name | gentamycin C1a |
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| Synonym | More Synonyms |
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gentamycin C1a BiologicalActivity
| Description | Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Gentamicin C1a 抑制 Escherichia coli,P. aeruginosa 和 S. aureus 活性，IC50 值为 1 mg/mL[2]。 Gentamicin C1a (2 mM, 48 h) 对 OC-k3 细胞活力没有影响[2]. |
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| In Vivo | Gentamicin C1a (4 mg/kg，静脉推注剂量，单次) 在比格犬体内的平均停留时间为 84 分钟，CL 值为 1.81 mL/min/kg[3]。 |
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| References | [1]. Li D, et al. Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. Microbiol Res. 2013 Jun 12;168(5):263-7. [2]. Ishikawa M, et al. Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use. Sci Rep. 2019 Feb 20;9(1):2410. [3]. Isoherranen N, et al. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44(6):1443-7. |
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Chemical & Physical Properties
| Density | 1.36g/cm3 |
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| Boiling Point | 675.2ºC at 760 mmHg |
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| Melting Point | 102-108ºC |
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| Molecular Formula | C19H39N5O7 |
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| Molecular Weight | 449.54200 |
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| Flash Point | 362.1ºC |
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| Exact Mass | 449.28500 |
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| PSA | 213.72000 |
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| Vapour Pressure | 3.97E-21mmHg at 25°C |
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| Index of Refraction | 1.603 |
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| InChIKey | VEGXETMJINRLTH-BOZYPMBZSA-N |
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| SMILES | CNC1C(O)C(OC2C(N)CC(N)C(OC3OC(CN)CCC3N)C2O)OCC1(C)O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- WK2290000
- CHEMICAL NAME :
- D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopy ranosyl-(1-6)-O-(2,6- diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyrano syl-(1-4))-2-deoxy-
- CAS REGISTRY NUMBER :
- 26098-04-4
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C19-H39-N5-O7
- MOLECULAR WEIGHT :
- 449.63
- WISWESSER LINE NOTATION :
- T6OTJ CQ DM1 EQ E1 BO- BL6TJ AZ CQ EZ DO- BT6OTJ CZ F1Z
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,239,1977
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Safety Information
| Hazard Codes | Xn |
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| HS Code | 3004909090 |
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Customs
Synonyms
| Geneticin C1a |
| Gentamicin C1a Pentaacetate Salt |
| GentaMycin C1a Acetate |
| Gentamycin C1a |
| GentaMicin C3 Acetate |
| Gentamisin C3 |
| Gentamicin D |
| Gentamicin C1a |
| GentaMicin D Acetate |
| Gentamicin C3 |
