CAS 51165-05-0|Substance P (7-11)

Introduction：Basic information about CAS 51165-05-0|Substance P (7-11), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameSubstance P (7-11)
CAS Number51165-05-0Molecular Weight612.78300
Density1.207g/cm3Boiling Point1003.3ºC at 760 mmHg
Molecular FormulaC31H44N6O5SMelting Point/
MSDS/Flash Point560.6ºC

Names

NameN-(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)-2-[[2-[[2-[(2-amino-3-phenylpropanoyl)amino]-3-phenylpropanoyl]amino]acetyl]amino]-4-methylpentanamide
SynonymMore Synonyms

Substance P (7-11) BiologicalActivity

DescriptionSubstance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.
Related CatalogSignaling Pathways >>GPCR/G Protein >>Neurokinin ReceptorSignaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseasePeptides
In VitroSubstance P (7-11) increases PGE2 and collagenase production at concentrations greater than 1 μM. Substance P (7-11), but not intact SP, SP-(1-4), SP-(1-6), SP- (8-11) or SP-(9-1 1), nor the tachykinins NKA and NKB, causes an increase in the intracellular calcium concentration as measured by the fluorescent dye Fura-2. The maximal change in intracellular calcium induced by 10 μM Substance P (7-11) was 140±30 nM[1].
Cell AssayConfluent chondrocytes are incubated for 24 h with SP or Substance P (7-11). TIMP activity is inactivated following reduction and alkylation with 2 mM dithiothreitol and 5 mM iodoacetamide for 30 min at 37°C. Samples are subsequently dialysed. Latent collagenase is activated with 1 mM APt followed by inactivation with soy bean trypsin inhibitor. Collagenase is measured[1].
References

[1]. Halliday DA, et al. The substance P fragment SP-(7-11) increases prostaglandin E2, intracellular Ca2+ and collagenase production in bovine articular chondrocytes. Biochem J. 1993 May 15;292 ( Pt 1):57-62.

Chemical & Physical Properties

Density1.207g/cm3
Boiling Point1003.3ºC at 760 mmHg
Molecular FormulaC31H44N6O5S
Molecular Weight612.78300
Flash Point560.6ºC
Exact Mass612.30900
PSA210.81000
LogP3.61840
Index of Refraction1.577
InChIKeyRBKYMAQIAMFDOE-CQJMVLFOSA-N
SMILESCSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(N)Cc1ccccc1)C(N)=O
Storage condition2-8℃

Synonyms

Substance P (7-11)
Penta-Substance P
Phe-Phe-Gly-Leu-Met-NH2
SUBSTANCE P,Fragment 7-11
2-{2-[2-(2-amino-3-phenylpropanamido)-3-phenylpropanamido]acetamido}-N-[1-carbamoyl-3-(methylsulfanyl)propyl]-4-methylpentanamide
H-Phe-Phe-Gly-Leu-Met-NH2
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