Introduction：Basic information about CAS 122929-08-2|Corazonin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Corazonin |
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| CAS Number | 122929-08-2 | Molecular Weight | 1369.44000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C62H84N18O18 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | corazonin |
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| Synonym | More Synonyms |
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Corazonin BiologicalActivity
| Description | Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species[1][2]. |
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| Related Catalog | Research Areas >>Neurological Disease |
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| In Vitro | Corazonin 是由侧脑神经分泌细胞投射到心体-语料体复合体和腹侧神经束神经元中产生的[1]。 Corazonin 在卵母细胞中激发内向电流 (EC50=200 pM)，并导致 CHO细胞的发光响应 (EC50=75 pM)[1]。 |
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| In Vivo | Corazonin (5.4 ng/脑室; 注射法; 单剂量) 在过渡期的哈氏牙鲆个体中，抑制大脑中卵黄蛋白原的表达，并刺激类似工人的狩猎行为，同时抑制决斗和卵子沉积等斗兽类行为[2]。 |
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| References | [1]. Kim YJ, et al. Corazonin receptor signaling in ecdysis initiation. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6704-9. [2]. Gospocic J, et al. The Neuropeptide Corazonin Controls Social Behavior and Caste Identity in Ants. Cell. 2017 Aug 10;170(4):748-759.e12. |
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Chemical & Physical Properties
| Molecular Formula | C62H84N18O18 |
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| Molecular Weight | 1369.44000 |
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| Exact Mass | 1368.62000 |
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| PSA | 607.98000 |
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| InChIKey | UOABGUNWRLWTJU-YPKDOBRCSA-N |
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| SMILES | CC(O)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C(CCCN=C(N)N)NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C1CCC(=O)N1)C(C)O)C(=O)NC(CC(N)=O)C(N)=O |
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| Storage condition | −20°C |
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Safety Information
Synonyms
| PYR-TFQYSRGWTN-NH2 |
| GLP-THR-PHE-GLN-TYR-SER-ARG-GLY-TRP-THR-ASN-NH2 |
| PGLU-THR-PHE-GLN-TYR-SER-ARG-GLY-TRP-THR-ASN-NH2 |
| PYR-THR-PHE-GLN-TYR-SER-ARG-GLY-TRP-THR-ASN-NH2 |
| MFCD00133199 |
