Introduction：Basic information about CAS 116783-35-8|Fmoc-Thr[GalNAc(Ac)3-α-D]-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fmoc-Thr[GalNAc(Ac)3-α-D]-OH |
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| CAS Number | 116783-35-8 | Molecular Weight | 670.660 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 857.1±65.0 °C at 760 mmHg |
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| Molecular Formula | C33H38N2O13 | Melting Point | 178-183 °C |
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| MSDS | / | Flash Point | 472.1±34.3 °C |
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Names
| Name | N-Fmoc-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-threonine |
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| Synonym | More Synonyms |
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Fmoc-Thr[GalNAc(Ac)3-α-D]-OH BiologicalActivity
| Description | Fmoc-Thr[GalNAc(Ac)3-α-D]-OH i a building block in the development of cancer vaccine. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>CancerResearch Areas >>Inflammation/ImmunologyPeptides |
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| In Vitro | The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome[1]. |
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| References | [1]. Ju T, et al. The Cosmc connection to the Tn antigen in cancer. Cancer Biomark. 2014 Jan 1;14(1):63-81. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 857.1±65.0 °C at 760 mmHg |
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| Melting Point | 178-183 °C |
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| Molecular Formula | C33H38N2O13 |
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| Molecular Weight | 670.660 |
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| Flash Point | 472.1±34.3 °C |
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| Exact Mass | 670.237366 |
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| PSA | 202.09000 |
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| LogP | 4.58 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.592 |
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| InChIKey | OXLCJWGAUPPZQJ-ZNHCDWFHSA-N |
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| SMILES | CC(=O)NC1C(OC(C)C(NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)OC(COC(C)=O)C(OC(C)=O)C1OC(C)=O |
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| Storage condition | -15°C |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| FMOC-THR(GALNAC(AC)3-α-D)-OH |
| α-D-Galactopyranoside, (1R,2S)-2-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-methylethyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate |
| (2R,3R)-3-{[(2S,3R,4R,5R,6R)-3-Acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butanoic acid (non-preferred name) |
| (2S,3R)-3-{[(2S,3R,4R,5R,6R)-3-Acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butanoic acid |
| α-D-Galactopyranoside, (1R,2R)-2-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-methylethyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate |
| Fmoc-Thr[GalNAc(Ac)3-α-D]-OH |
