Introduction：Basic information about CAS 80-75-1|Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)- |
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| CAS Number | 80-75-1 | Molecular Weight | 330.46 |
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| Density | 1.15 g/cm3 | Boiling Point | 487.4ºC at 760 mmHg |
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| Molecular Formula | C21H30O3 | Melting Point | 165-166ºC(lit.) |
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| MSDS | / | Flash Point | 262.7ºC |
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Names
| Name | 11α-hydroxyprogesterone |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | 11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
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| References | [1]. Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62(6):1306-13. [2]. Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27(3 Pt 1):421-5. |
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Chemical & Physical Properties
| Density | 1.15 g/cm3 |
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| Boiling Point | 487.4ºC at 760 mmHg |
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| Melting Point | 165-166ºC(lit.) |
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| Molecular Formula | C21H30O3 |
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| Molecular Weight | 330.46 |
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| Flash Point | 262.7ºC |
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| Exact Mass | 330.21900 |
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| PSA | 54.37000 |
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| LogP | 3.69430 |
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| Index of Refraction | 1.557 |
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| InChIKey | BFZHCUBIASXHPK-QJSKAATBSA-N |
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| SMILES | CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C |
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| Storage condition | Refrigerator |
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Safety Information
| Safety Phrases | S24/25 |
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| WGK Germany | 3 |
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| RTECS | TU5057000 |
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Synonyms
| 11alpha-hydroxyprogesterone |
| HYDROXYPROGESTERONE,11A |
| DG 322B |
| 11A-HYDROXYPROGESTERONE |
| EINECS 201-306-9 |
| 4-PREGNEN-11A-OL-3,20-DIONE |
| MFCD00003652 |
| Progesterone,11alpha-hydroxy |
| Progesterone, 11.α.-hydroxy- |
| U 0384 |
