CAS 1259-86-5|Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-15-[(2S)-2-hydroxy-2-methyl-1-o

Introduction：Basic information about CAS 1259-86-5|Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-15-[(2S)-2-hydroxy-2-methyl-1-o, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-15-[(2S)-2-hydroxy-2-methyl-1-oxobutoxy]-, (1b,11b,12a,15b)- (9CI)
CAS Number	1259-86-5	Molecular Weight	494.53100
Density	1.44g/cm3	Boiling Point	714.1ºC at 760mmHg
Molecular Formula	C₂₅H₃₄O₁₀	Melting Point	/
MSDS	/	Flash Point	240.7ºC

Names

Name	Butyric acid, 2-hydroxy-2-methyl-, 4-ester with 1,3ab,4,7,7aa,11,11a,11ba-octahydro-1a,2a,4b,11b-tetrahydroxy-3a,8,11ab-trimethyl-2H-1,11cb-(epoxymethano)phenanthro[10,1-bc]pyran-5,10(3H,6abH)-dione
Synonym	More Synonyms

BiologicalActivity

Description	(+)-Glaucarubinone is a potent AP-1 (activator protein-1) inhibitor with an EC50 value of 0.13 µM. (+)-Glaucarubinone shows noncytotoxic[1].
Related Catalog	Research Areas >>Cancer
Target	EC50: 0.13 µM (AP-1)[1]
References	[1]. Diyabalanage T, et al. Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4397-9.

Chemical & Physical Properties

Density	1.44g/cm3
Boiling Point	714.1ºC at 760mmHg
Molecular Formula	C₂₅H₃₄O₁₀
Molecular Weight	494.53100
Flash Point	240.7ºC
Exact Mass	494.21500
PSA	159.82000
Vapour Pressure	1.47E-23mmHg at 25°C
Index of Refraction	1.611
InChIKey	WRBGCYVAJRRQKP-OKWDTJBHSA-N
SMILES	CCC(C)(O)C(=O)OC1C(=O)OC2CC3C(C)=CC(=O)C(O)C3(C)C3C4(O)OCC23C1C(C)C4O

Synonyms

glaucarubinone

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