CAS 40126-30-5|H-cis-Hyp-OMe hydrochloride

Introduction：Basic information about CAS 40126-30-5|H-cis-Hyp-OMe hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. H-cis-Hyp-OMe hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	H-cis-Hyp-OMe hydrochloride
CAS Number	40126-30-5	Molecular Weight	181.617
Density	/	Boiling Point	282.3ºC at 760 mmHg
Molecular Formula	C₆H₁₂ClNO₃	Melting Point	/
MSDS	/	Flash Point	124.5ºC

Names

Name	H-Cis-Hyp-Ome Hcl
Synonym	More Synonyms

H-cis-Hyp-OMe hydrochloride BiologicalActivity

Description	H-cis-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-cis-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR
Related Catalog	Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

Boiling Point	282.3ºC at 760 mmHg
Molecular Formula	C₆H₁₂ClNO₃
Molecular Weight	181.617
Flash Point	124.5ºC
Exact Mass	181.050568
PSA	58.56000
LogP	0.01300
InChIKey	KLGSHNXEUZOKHH-FHAQVOQBSA-N
SMILES	COC(=O)C1CC(O)CN1.Cl
Storage condition	2-8°C

Safety Information

Hazard Codes	Xi

Synonyms

H-cis-Hyp-OMe.HCl

Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (1:1)

Trans-4-hydroxy-L-proline methyl ester hydrochloride

Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1)

L-Proline, 4-hydroxy-, methyl ester, (4S)-, hydrochloride (1:1)

L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1)

(2S,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

methyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate,hydrochloride

cis-4-Hydroxy-L-proline methyl ester hydrochloride

Recommended......